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Synthesis of Enol ether,α,β-unsaturated carbonyl compound, Oxoketenedithio acetal and Dimethyl aminomethylene ketone derivatives of s-Triazines as Intermediates for Synthesis of Fused Heterocycles

Author Affiliations

  • 1Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan, 304 022, INDIA
  • 2 Department of Pure and Applied Chemistry, University of Kota, Rajasthan, 324 005, INDIA

Res.J.chem.sci., Volume 5, Issue (11), Pages 9-12, November,18 (2015)


The synthesis of enol-ether, αβ-unsaturated carbonyl compound,oxoketenedithio acetaland dimethyl aminomethylene ketonederivatives of quinazoline and pyrimidine containing trisubstituted s-triazines. Apart from this, quinazoline and pyrimidine containing trisubstituted s-triazine template has also been used to synthesize quinoline-4-carboxylic acid moiety and diazepinone derivatives by adopting the Pfitzinger reaction and Beckmannrearrangement methodology. The structures of all the compounds have been confirmed by elemental analysis and spectral data.


  1. Katritzky A.R., Bayyuk S.I. and Rachwal S., An efficient synthesis of ketone enol ethers mediated by N-(1-Alkoxyalyl) benzonitriles, Synthesis, 279-283 (1991)
  2. Bonacorso H.G., Wastowski A.D., Zanatta N., Martins M.A.P. and Naue J.A., Haloacetylated enol ethers 10. Condensation of b-alkoxyvinyl tri-uoromethyl ketones with thiosemicarbazide. Synthesis of new tri-uoromethyl 4,5-dihydro-1H-1 pyrazolethiocarboxyamides, J. Fluorine Chem.,92, 23-26 (1998)
  3. In J.K., Lee M.S., Lee M.W., Kwak J.H., Lee H., Hong J.T., Chung Y., Choi Y. and Jung J.K., Stereoselective synthesis of (E)- and (Z)-enol ethers from -amino aldehydes, Arch. Pharm. Res.,30(6), 695-700 (2007)
  4. Juan R., Legros, J. and Bolm C., Synthesis of enamines, enol ethers and related compounds by cross-coupling reactions, Chem. Commun., 973-986 (2005)
  5. Patil C.B., Mahajan S.K. and Katti S.A., Chalcone: A versatile molecule, J. Pharm. Sci. Res., l1(3), 11-22 (2009)
  6. Baviskar B.A., Baviskar B., Shiradkar M.R., Deokate U.A. and Khadabadi S.S., Synthesis and antimicrobial activity of some novel benzimidazolyl chalcones, E-Journal Chem.,6(1), 196-200 (2009)
  7. Mu1ller T.J.J., Braun R. and Ansorge M., A novel three-component one-pot pyrimidine synthesis based upon a coupling-isomerization sequence, Org. Lett.,2(13), 1967-1970 (2000)
  8. Mathews A., Anabha E.R. and Sholly C.G., A facile method for the synthesis of oxoketene-N,S- and -N,Nacetals from reactions of amino compounds, Org. Chem.,1-5 (2010)
  9. Mehta B.K., Nandi S., lla H. and Junjappa H, Highly regioselective 1,2-addition of alkoxybenzyl Grignard reagents to -oxoketene dithioacetals: A facile regiocontrolled synthesis of alkoxynaphthalenes and their condensed analogs via aromatic annelation, Tetrahedron,55, 12843-12852 (1999)
  10. Chen H.S., Li Z.M. and Wang Z.W., A convenient synthesis of pyrazolylpyrazoles using -oxoketene S,S- and N,S-acetals, Chinese Chem. Lett.,10(8), 643646 (1999)
  11. Zhao M.X., Liu Q., Hu Y.L. and Li D.L., -Oxoketene dithioacetals chemistry-A facile route to the synthesis of fused heterocyclic compounds, Chinese Chem. Lett., 11(4), 283-284 (2000)
  12. Hassneen H.M.and Abdallah T.A., New routes to pyridino[2,3-d]pyrimidin-4-one and pyridino-[2,3-d] triazolino [4,5-a] pyrimidin-5-one derivatives, Molecules,8, 333-341 (2003)
  13. Jiang J.L, Ju J. and Hua R., A highly efficient cycloaddition of vinylarenes with electron-deficient alkynes affording 1,2-disubstituted-3,4-dihydronaphthalenes catalysed by dimethylformamide dimethyl acetal, Org. Biomol. Chem., 5, 1854-1857 (2007)
  14. Dzhavakhishvili S.G., Gorobets N.Y., Chernenko V.N., Musatov V.I. and Desenko S.M., Synthesis of novel 3(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)-diones, Russian Chem. Bull., 57(2), 422-427 (2008)
  15. Wang D.L., Gu Z., Xu J., Han S. and Imafuku K., New synthetic approach to 4-N-arylaminoazuleno[2,1-d]pyrimides, Synthetic Commun.,39, 2329-2338 (2009)
  16. Shekhawat S., Sharma A., Kishore D. and Singh B., Synthesis of trisubstituted s-triazine templates to prepare some reactive intermediates for the synthesis of medicinally potent novel heterocycles, J. Chem. Chem. Sci.,5(9), 517-521 (2015)