Imidazole and its derivatives and Importance in the Synthesis of Pharmaceuticals: A Review

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Imidazole and its derivatives and Importance in the Synthesis of Pharmaceuticals: A Review

Suvarna Arunkumar S

Author Affiliations

¹Medigrapha Pharamaceuticals Pvt Ltd, Maharastra, INDIA

Res.J.chem.sci., Volume 5, Issue (10), Pages 67-72, October,18 (2015)

Abstract

The term “Imidazole” has gained importance in the modern world with its ability to explore various pharmacological potentials. The importance of the term ‘Imidazole” and its derivates are popular since past few years with the synthesis of pharmaceuticals and treatment of various diseases. The imidazole ring occurs in a number of naturally occurring compounds, and very widely distributed in essentials amino acids, L-histidine and its derivatives have powerful pharmacological properties. Purins, present in living systems contain the imidazole ring.

References

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Hoffman K., imidazoles and its derivatives, Interscience, New York, 143-145 (1953)
Bredereck H., Gompper R. and Hayer D., Chem. Be,92, 338 (1959)
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Finar I.L., Stereochemistry and chemistry of natural products, Organic chemistry,, 622-629 (2015)
Kartaraski, Comp. Hetro, Chem.,, 345-498 (1984)
Jain M.K. and Sharma S.C., Modern Organic Chemistry, vishal publication, 809 (2005)
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Suzuki F., Kuroda T. and Tamura T., J. Med. Chem.,35(15), 2863-2870 (1992)
George B., Synthesis of 4,5-Substituted Imidazoles by a Fast Condensation of 1,2-Diketones Urotropine HeterogeneousMedium, Chemlnform,40(50), 2319-2320 (2009)
Zuliani V., Cocconcelli G., Fantini M., Ghiron C. and Rivara M., APractical Synthesis of 2, 4(5)-Diary limidazoles From Simole Building Blocks, J. Org., (72), 4551-4553 (2007)
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Zhu L, Li G, Luo L, Guo P, Lan J and You J., HighlyFunctionalGroup Tolerance in Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles under Mild Conditions (2009)
Yanagisawa H, Amemiya Y, Kanazaki T, Fujimoto K and Shimoji Y, Fujimoto Y et al. Angiotensin II receptor antagonists:imidazoles and pyrroles bearing hydroxymethyl and carboxysubstituents, Bioorg, Med. Chem. b Lett,4(1), 177-182 (1994)
Khabnadideh S, Rezaei Z, Khalafi-Nezhad A, Bahrinajafi R,Mohamadi R and Farrokhroz AA., Synthesis ofN-Alkylatedderivatives of imidazole as antibacterial agents, Bioorg MedChem Lett., 13(17),2863-2865 (2003)
Li T.HwangR., SongS.Chen CP. Chuu J. and Hu C et al., Synthesis and biological Activities of 2-amino-1- arylidenamino imidazoles asorallyactiveanticancer agents, ChenJ.Med. Chem.,53(6), 24092417 (2010)

[ref1] Lunt E., Newton C.G., Smith C., Stevens G.P., Stevens M.F., Straw C.G., Walsh R.J., Warren P.J., Fizames C., Lavelle F., J. Med. Chem.,30 (2), 357-366 (1987)

[ref2] Hoffman K., imidazoles and its derivatives, Interscience, New York, 143-145 (1953)

[ref3] Bredereck H., Gompper R. and Hayer D., Chem. Be,92, 338 (1959)

[ref4] Robert C. Elderfield, 5- membered heterocycles combining two heteroatoms and their benzo, Derivatives, heterocyclic compound, 744 (1957)

[ref5] Finar I.L., Stereochemistry and chemistry of natural products, Organic chemistry,, 622-629 (2015)

[ref6] Kartaraski, Comp. Hetro, Chem.,, 345-498 (1984)

[ref7] Jain M.K. and Sharma S.C., Modern Organic Chemistry, vishal publication, 809 (2005)

[ref8] Suzuki M., Maeda S. and Matsumoto K., Boll chem. farm , 34(8), 3111-3120 (1986)

[ref9] Suzuki F., Kuroda T. and Tamura T., J. Med. Chem.,35(15), 2863-2870 (1992)

[ref10] George B., Synthesis of 4,5-Substituted Imidazoles by a Fast Condensation of 1,2-Diketones Urotropine HeterogeneousMedium, Chemlnform,40(50), 2319-2320 (2009)

[ref11] Zuliani V., Cocconcelli G., Fantini M., Ghiron C. and Rivara M., APractical Synthesis of 2, 4(5)-Diary limidazoles From Simole Building Blocks, J. Org., (72), 4551-4553 (2007)

[ref12] Siddiqui SA, Narkhede UC, Palimkar SS, Daniel T, Lahoti RJ and Srinivasan KV., Room temperature ionic liquid promotedimproved and rapid synthesis of 2,4,5-triaryl imidazoles fromaryl aldehydes and 1,2- diketones or a-hydroxyketone, Tetrahedron,61, 3539-3546 (2005)

[ref13] Ishihara M and Togo H., An Efficient Preparation of 2-lmidazolinesand Imidazoles from Aldehydes withMolecular Iodine andbenzene, Synlett, 227-230 (2006)

[ref14] Zhu L, Li G, Luo L, Guo P, Lan J and You J., HighlyFunctionalGroup Tolerance in Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles under Mild Conditions (2009)

[ref15] Yanagisawa H, Amemiya Y, Kanazaki T, Fujimoto K and Shimoji Y, Fujimoto Y et al. Angiotensin II receptor antagonists:imidazoles and pyrroles bearing hydroxymethyl and carboxysubstituents, Bioorg, Med. Chem. b Lett,4(1), 177-182 (1994)

[ref16] Khabnadideh S, Rezaei Z, Khalafi-Nezhad A, Bahrinajafi R,Mohamadi R and Farrokhroz AA., Synthesis ofN-Alkylatedderivatives of imidazole as antibacterial agents, Bioorg MedChem Lett., 13(17),2863-2865 (2003)

[ref17] Li T.HwangR., SongS.Chen CP. Chuu J. and Hu C et al., Synthesis and biological Activities of 2-amino-1- arylidenamino imidazoles asorallyactiveanticancer agents, ChenJ.Med. Chem.,53(6), 24092417 (2010)