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Comparative QSAR study of Anthracycline Analogues

Author Affiliations

    Res.J.chem.sci., Volume 4, Issue (6), Pages 18-22, June,18 (2014)

    Abstract

    Anthracycline, a potent anticancer molecule being used extensively in chemotherapy, though known for its efficacy known to cause adverse effects when administered. We are trying to analyse the variations in its analogues structurally. To study the QSAR of anthracycline analogues by using graph theoretical indices and physicochemical properties efforts have been made to derive a best mathematical model for the calculation of biological activity of the analogues in multivariate form. We have used multiple linear regression method. Two equations were developed separately, 1. Containing graph theoretical indices with r value 0.7038 and 2. Containing physicochemical properties as predictor variable with r value 0.8162 both models are significant to understand QSAR of anthracycline analogues.

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