International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Studies of Some Mixed ligand Ternary Metal Complexes of N Acetyl Cysteine with Zinc (II) and Nickel (II) Metal ions

Author Affiliations

  • 1 Department of Chemistry, University of Kashmir, Srinagar, INDIA

Res.J.chem.sci., Volume 4, Issue (3), Pages 32-35, March,18 (2014)

Abstract

Mixed metal complexes of N acetyl cysteine as a primary ligand and some amino acids such as alanine, methionine, tryptophan, aspartic acid and glutamic acid used as secondary ligands with metal ions zinc (II) and nickel (II) were synthesized. The prepared ternary complexes were characterized by elemental analysis, thermal analysis, molar conductivity measurement and IR, UV-Visible spectral studies. The spectral studies indicated octahedral geometry for nickel (II) complexes and a tetrahedral geometry was proposed for zinc (II) complexes.

References

  1. Gehad G.M, Hanan F.A, Maher M.I.E, Walaa H.M., Synthesis and characterization of mixed ligand complexes of lomefloxacin drug and glycine with transition metals. Antibacterial, antifungal and cytotoxicity studies, Journal of Molecular Structure, 999(1), 29-38 (2011)
  2. Wang M.Z, Meng Z.X, Liu B.L, Cai G.L, Zhang C.L, Wang X.Y., Novel tumor chemotherapeutic agents and tumor radio-imaging agents: potential tumor pharmaceuticals of ternary copper (II) complexes, Inorganic chemistry communications, 8(4), 368-371 (2005)
  3. Patil SS, Thakur GA, Patil VR. Synthesis, spectral and biological studies on some mixed ligand Ni (II)complexes, Acta Pol Pharm., 66(3), 271-77(2009)
  4. Sharma R, Nagar M, Agarwal M, Sharma H., Synthesis, characterization and antimicrobial activities of some mixed ligand complexes of Co(II) with thiosemicarbazones and N-protected amino acids, J Enzyme Inhib Med Chem., 24(1),197-204 (2009)
  5. Badar T.K, Najmuddin K, Shamsuddin S, Annapoorna K, Jayshree B.,Synthesis, antimicrobial, and antitumor activity of a series of palladium(II) mixed ligand complexes, Journal of Inorganic Biochemistry, 44(1), 55-63 (1991)
  6. Mrinalini L, Manihar Singh A.K., Mixed Ligand Cobalt (III) Complexes with 1-Amidino-O-Methylurea and Amino Acids, Res.J.chem.sci.,2(1), 45-49 (2012)
  7. Schubert J., Chelating agents in biological systems, Environmental health perspectives., 40, 227-232 (1981)
  8. Hallman P.S, Perrin D.D, Watt A.E., The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma, Biochem.J., 121(3), 549-55 (1971)
  9. Chang S, Karambelkar V.V, Sommer R.D, Rheingold A. L. and Goldberg D.P., New monomeric cobalt (II) and zinc (II) complexes of a mixed N,S(alkylthiolate) ligand: model complexes of (His) (His) (Cys) metalloprotein active sites, Inorg. Chem., 41, 239-248 (2002)
  10. Ralph A. B, William T. S, Frank R. N. G., Sites of binding of copper(II) ion by peptide (124) of bovine serum albumin, J. Biol. Chem.,243, 3817-3825 (1968)
  11. Geary W. J., Use of Conductivity Measurements in Organic Solvents for the Characterization of Coordination Compounds, Coord. Chem. Rev., 7,81-122 (1971)
  12. Nakamoto K., Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th Ed., John Wiley & Sons: New York, (1986)
  13. Cotton F.A, Wilkinson G, Murillo C.A, Bochmann M., Advanced Inorganic Chemistry, 6th ed., Wiley: New York, (1999)
  14. Lever A.B.P., Inorganic Electronic Spectroscopy, 1st ed., Elsevier: Amsterdam, (1968)