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Skin irritation study due to Electron beam cured Polyurethane based Pressure sensitive Adhesive tape in Oryctolagus cuniculus

Author Affiliations

  • 1Shriram Institute for Industrial Research, 19-University Road, Delhi-110007, INDIA
  • 2Centre of Mining Environment, Dept. of Environmental Science and Engineering, Indian School of Mines, Dhanbad, Jharkhand-826004, INDIA

Res.J.chem.sci., Volume 4, Issue (3), Pages 54-59, March,18 (2014)

Abstract

Pressure sensitive adhesives (PSAs) have an important role in health care industry and are used in a range of medical applications from low tack PSA tapes to high tack implant adhesives. Biocompatibility of such medical devices is an urgent requirement of many agencies since, used on human body. Therefore, the materials that come in contact must be evaluated and determined to be safe for use, which may leach off of a device into adjacent tissue. Some leachables are not biologically safe and can harm the body after or during application. The study helps to determine whether materials that causes adverse effects, has immense importance before commercialization of product. In the present study an attempt has been made to assess skin irritation of a microporous PSA tape made of polyurethane (PU) acrylate by electron beam (e-beam) irradiation process. The results of the study may help in predicting the irritation potential of the test item in humans or higher mammals.

References

  1. Stephen E., Krampe, Cheryl L., Moore, Charles W. and Taylor, Macromer reinforced pressure sensitive skin adhesive sheet material, Minnesota Mining and Manufacturing Company, US 4732808 A(1988)
  2. Singh A.K., Mehra D.S., Niyogi U.K., Sabharwal S. and Khandal R.K., Polyurethane based pressure sensitive adhesives (PSAs) using e-beam irradiation for medical application, J. Polym. Material., 28(4), 525-542 (2011)
  3. Kydonieus A., Park K., Shah K. and Nathan A., Polyurethane pressure sensitive adhesives, Bristol-Myers Squibb Company, US 005910536A(1999)
  4. Vermette P., Griesser H.J., Laroche G. and Guidoin R., Biomedical applications of polyurethanes, Tissue engineering intelligence unit 6, Eurekah.com, Landes Bioscience Georgetown, Texas, U.S.A. (2001)
  5. Singh A.K., Mehra D.S., Niyogi U.K., Sabharwal S. and Khandal R.K., Effect of tackifier and crosslinkers on electron beam curable polyurethane pressure sensitive adhesive, Radiat. Phys. Chem., 81(5), 547552 (2012)
  6. Singh A.K., Mehra D.S., Niyogi U.K., Sabharwal S., Swiderska J., Czech Z. and Khandal R. K., Effect of crosslinkers on adhesion properties of electron beam curable polyurethane pressure sensitive adhesive, Int. J. Adhes. Adhes., 41, 7379 (2013)
  7. Singh A.K., Niyogi U.K., Sabharwal S., Kowalczyk A., Czech Z. and Mehra D. S., Shrinkage studies in electron beam curable polyurethane pressure sensitive adhesive, J. Adhes. Sci. Technol.,27(14), 15111524 (2013)
  8. Fournier E., Passirani C., Montero-Menei C.N. and Benoit J.P., Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility, Biomater., 24(19), 3311-3331 (2003)
  9. Lebowitz M.D., Key concepts: Chemical Sensitization, In Multiple chemical sensitivities, National Academic Press,Washington (1992)
  10. Turner-Warwick M., On observing patterns of airflow obstruction in chronic asthma, Brit J. Dis. Chest.,71, 73-86 (1977)
  11. Ryan C.A., Hulette B.C. and Gerberick G.F., Approaches for the development of cell-based in vitro methods for contact sensitization, Toxicol. In Vitro., 15(1), 43-55 (2001)
  12. ISO 10993-1, Biological Evaluation of Medical Devices-Part-1: Evaluation and testing within a risk management process (2009)
  13. ISO 10993-2, Biological evaluation of Medical Devices- Part 2: Animal Welfare Requirements (2006)
  14. ISO 10993-10, Biological evaluation of medical devices-part 10: Tests for Skin Irritation and sensitization (2010)
  15. ISO 10993-12, Biological evaluation of medical devices-part 12: sample preparation, (2012)
  16. Draize J.H., Woodard G. and Calvery G.O., Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes, J. Pharm. Exp. Ther.,82, 377-390 (1944)