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Synthesis, Characterization and Antimicrobial studies of Transition metal complexes of Co(II) and Ni(II)derived from Cefadroxil

Author Affiliations

  • 1Govt. Nirbhay Singh Patel Science College, Indore, MP, INDIA
  • 2 Department of Chemistry, Sadhu Vaswani College, Bairagarh, Bhopal-462-030, MP, INDIA

Res.J.chem.sci., Volume 4, Issue (2), Pages 75-80, February,18 (2014)


Cefodroxil (CEFDX) is a broad spectrum cephalosporin belonging to the first generation antibiotic agents. In this study, attention has been paid to the synthesis, characterization and biological evaluation of new CoII and NiII complexes of CEFDX. The stoichiometrics and the mode of bonding of the complexes were deduced from their elemental and electrical conductivity measurements. For the characterization of the metal complexes various techniques like FTIR, UV-Vis Spectral study and TG-DSC were used. The composition of the complexes was identified as 1:1 ratio. Based on the study of infrared spectra, coordination through amide group and carboxylate group is proposed. Octahedral structures were proposed for these complexes depending upon the electronic spectral data. The thermal analysis data shows that water molecules have coordinate bonds with transition metal ion. Antimicrobial activity of thecomplexes was determined using Gram-positive strains of (Staphylococcus aureus) and Gram-negative strains of (Escherichia coli) bacteria by disc diffusion method.The antibacterial study of ligand and metal complexes were found to be better than the parent antibiotic.


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