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Synthesis and in vitro Antimicrobial Evaluation of 5'-Acetamido-2'-Hydroxy Chalcone derivatives

Author Affiliations

  • 1 Department of Microbiology, Melaka Manipal Medical College (Manipal Campus), Manipal University, Manipal, Karnataka, INDIA
  • 2 Department of Chemistry, Kasturba Medical College International Center, Manipal University, Manipal, Karnataka, INDIA
  • 3 Department of Chemistry, Shri Madhwa Vadiraja Institute of Technology and Management, Bantakal, Udupi , Karnataka, INDIA
  • 4 Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, INDIA

Res.J.chem.sci., Volume 4, Issue (2), Pages 56-59, February,18 (2014)


A series of chalcones (3a-j) were synthesized by Claisen-Schmidt condensation of aromatic aldehydes with 5-acetamido-2-hydroxyacetophenone. Paracetamol was acetylated using acetic anhydride and sulphuric acid. The acetylated paracetamol underwent Fries rearrangement to form 5-acetamido-2-hydroxy acetophenone. The antibacterial and antifungal activity of the test compounds were evaluated using the agar well diffusion method. The test compounds displayed activity against Candida albicans. The fluorinated chalcone 3c exhibited maximum inhibition. However the test compounds failed to show antibacterial activity.


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