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Synthesis and Characterization of Derivative derived from 1, 4-Dihydropyrimidine

Author Affiliations

  • 1AKI Poona College of Arts, Commerce and Science, Camp Pune-411001, Maharashtra, INDIA
  • 2Gokhale Education Society Arts, Commerce and Science College Shrivardhan-402110, Maharashtra, INDIA

Res.J.chem.sci., Volume 4, Issue (11), Pages 18-22, November,18 (2014)

Abstract

In our present work A new modification in biginelli product has been developed and formation as well as characterization of ethyl 2-(butylsulfanyl)-4- (4-hydroxyphenyl) -6-methyl-1, 4-dihydropyrimidine-5- carboxylate, ethyl-4- (4-bromophenyl)-2- (butylsulfanyl)-6-methyl-1, 4-dihydropyrimidine-5-carboxylate, ethyl-2-(butylsulfanyl)-6-methyl-4-phenyl-1, 4-dihydropyrimidine-5-carboxylate, ethyl2-(butylsulfanyl)-4- (4-fluorophenyl)-6-methyl-1, 4-dihydropyrimidine-5-carboxylate, ethyl-2-(butylsulfanyl)-6-methyl-4 (3-nitrophenyl)-1, 4-dihydropyrimidine-5-carboxylate. Involving linkage of n-butyl group to Sulphur atom which is having the same biological activity. The compound obtain in the first stage was subjected for further reaction with n-butyl bromide in presence of weak base pyridine.

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