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Green and Efficient protocol for Synthesis of Schiff bases and Hydroxyl Derivatives of 1,3,4-Thiadiazole containing n-Phenyl Piperazine moiety and their Antimicrobial and Antioxidant Potential

Author Affiliations

    Res.J.chem.sci., Volume 4, Issue (10), Pages 43-47, October,18 (2014)


    A new class of thiadiazole having combination of Schiff base and Mannich base containing N-phenyl piperazine moiety was synthesized by an efficient microwave assisted green synthetic approach. Antioxidant activity of methanol solutions of synthesized compounds was determined by Reducing power assay and Hydrogen peroxide scavenging activity at 700 nm and 250 nm respectively. The synthesized compounds were also screened for antbacterial activity and were characterized by FTIR, H NMR and elemental analysis.


    1. Karale B.K., Tarkate S.J., Salve S.P., Zaware B. H. and Jadhav S. S., Synthesis and biological screening of novel thiazolyl triazoles and thiadiazoles, Indian J. Chem.,53B, 339-344 (2014)
    2. Sah P., Bidawat P., Seth M. and Gharu C. P., Synthesis of formazans from Mannich base of 5-(4-chlorophenyl amino)-2-mercapto-1,3,4-thiadiazole as antimicrobial agents, Arab. J. Chem.,7, 181-187 (2014)
    3. Sah P. and Gharu C.P, Synthesis, characterization and antimicrobial evaluation of Schiff bases of 4-thiazolidinone bearing thiadiazole moiety, J. Cur. Pharm. Res., 9(1), 44-48 (2012)
    4. Talath S. and Gadad A. K., Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl]fluoroquinolonic derivatives, Eur. J. Med. Chem.,41, 918-924 (2006)
    5. Foroumadi A., Rineh A., Emami S., Siavoshi F., Massarrat S. and Safari F. et al., Synthesis and biological evaluation of novel benzyl piperazine derivatives of 5-(5-nitroaryl)-1,3,4-thiadiazoles as Anti-Helicobacter pylori agents., Bioorg. Med. Chem. Lett.,18, 3315-3320.(2008)
    6. Joshi N. K., Kundariya D.S. and Parmar J.M., Synthesis, characterization and anti-microbial evaluation of some novel 1,3,4-oxadiazoles containing piperazine moiety, International. J. Chem. Tech. Res.,4(4), 1503-1508 (2012)
    7. Savaliya M. D., Dobariya J. G., Patolia V. N., Patel A. U. and Purohit D. M., Synthesis and antimicrobial activity of 1-(aroyl/ arylsulpho/ arylaminomethyl)-4-[(4',4"-difluorodiphenyl) -methyl]-piperazines., Organic Chemistry, An Indian J.,Vol. 5(1), 100-103 (2009)
    8. Sah P. and Gharu C. P., Pharmacological potential of mannich bases of 1,3,4- oxadiazole bearing benzimidazole and piperazine Moieties, Paripex Indian J. Res.,2(3), 15-17 (2013)
    9. Saravanan G., Alagarsamy V., Prakash C. R., Synthesis and evaluation of antioxidant activities of novel quinazolinone derivatives., Int. J. Pharm. Pharm. Sci.,2(4), 83-86 (2010)
    10. Rajasekaran S. and Rao G.K., Synthesis, antibacterial and antioxidant activity of some 2,3-substituted quinazolin-4(3H)-ones, Der. Pharmacia. Lett.,4(1), 349-353 (2012)
    11. Hossain M. M. and Kumar S., Antioxidant potential study of some synthesized N-heterocycles, Bangladesh Med. Res. Counc. Bull., 35, 49-52 (2009)
    12. Oyaizu M., Studies on product of browning reaction prepared from glucose amine, Jpn, J. Nut.,44, 307-315 (1986)
    13. Ruch R. T,, Cheng S. J. and Klaunig J. E., Spin trapping of superoxide and hydroxyl radicals, Meth. Enzym., 105, 198-209 (1984)
    14. Barry A. L., Joyce L. J., Adams A. P. and Benner E. J.,Rapid determination of antimicrobial susceptibility for urgent clinical situations, Amer. J. Clin. Pathol, 45, 493(1973)