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Synthesis of Bio-Active Guanidines by using Dioxane- Dibromide (Ddb) Under Ultrasound conditions

Author Affiliations

  • 1 Chemistry department, College of Natural Science, P.O.Box 378, Jimma University, Jimma, ETHIOPIA

Res.J.chem.sci., Volume 4, Issue (10), Pages 48-53, October,18 (2014)

Abstract

Over the decades guanidine and its derivatives have gained wide applications in organic synthesis, in the field of immunology andorgano electronics. In this paper, we highlight the facile conversion of 1,3-disubstituted thioureas to symmetric and non-symmetric guanidine derivatives by using dioxane-dibromide (DDB) as an oxidant with various amines under ultrasound conditions. The guanidines were obtained with quantitative yield, less reaction time, we also described further elaboration of this method for the synthesis of protected guanidine derivatives. All synthesized guanidines were tested for their invitro antimicrobial activity against Staphylococcus aureus, Staphylococcus albus, Klebsiella pneumonia Salmonella typhiand antifungal activity against Candida albicans, Aspergillusclavatusduring 48 h incubation period.

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