International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis and Antimicrobial Activity of some Salicylaldehyde Schiff bases of 2-aminopyridine

    , ,

Author Affiliations

  • 1Department of Chemistry, Agra College, Agra, UP, INDIA
  • 2Department of Chemistry, B.K. Birla Institute of Engineering and Technology, Pilani, Rajasthan, INDIA

Res.J.chem.sci., Volume 3, Issue (9), Pages 26-29, September,18 (2013)

Abstract

Schiff bases particularly (1) N-(2-hydroxylbenzylidene) pyridin-2-amine, (2) N-(5-nitro-2- hydroxylbenzylidene) pyridin-2-amine, (3) N-(5-bromo-2- hydroxylbenzylidene) pyridin-2-amine, (4) N- (5-methoxy-2-hydroxylbenzylidene) pyridin-2-amine are prepared from 2- aminopyridine and substituted benzyaldehydes. The synthesized compounds are characterized by elemental analysis, IR and HNMR. The result shows that the compounds are capable to prevent the growth of S. aureus and E. coli in diverse concentrations. The growth prevention capability was affected by the solvent and substitute group on the salicyldene part.

References

  1. Gupta Y. K.*, Agarwal S.C., Madnawat S.P. and Ram Narain, Synthesis, Characterization and Antimicrobial Studies of Some Transition Metal Complexes of Schiff Bases, Res. J. Chem. Sci., 2(4)68-71, April (2012)
  2. Parekh J, Inamdhar P, Nair R, Baluja S, Chanda S, Synthesis and antibacterial activity of some Schiff bases derived from 4-aminobenzoic acid, J. Serb. Chem. Soc., 70,1155-1161(2005)
  3. Sinha D, Tiwari AK, Singh S, Shukia G, Mishra P, Chandra H, Mishra AK, Synthesis, characterization and biological activity of Schiff base analogue of indole-3- carboxaldehyde, Eur. J. Med. Chem., 43, 160-165, (2008)
  4. Gupta Yogesh Kumar*, Gupta Vinita and Singh Sanchita, Synthesis, characterization and antimicrobial activity of pyrimidine based derivatives, Journal of Pharmacy Research, Elsevier7(6), 491-495 (2013)
  5. Hou H, Zhu J, Qi Z, Zhou B, Li M, Liu Y, Antibacterial activity and structure-activity relationship of Schiff bases on Staphylococcus aureus by microcalorimetery, Wuhan Univ. J. Nat. Sci.,15, 71-77 (2010)
  6. Aggarwal N, Kumar R, Dureja P, Rawat DS, Schiff base as potential fungicides and nitrification inhibitors, J. Agric. Food Chem.,57, 8520-8525 (2009)
  7. Adsule S, Barve V, Chen D, Ahmed F, Dou QP, Padhye S,Sarkar FH, Novel Schiff base copper complexes of quinoline-2-carboxaldehyde as proteasome inhibitors in Human prostate cancer cells, J. Med. Chem.,49, 7242- 7246 (2006)
  8. Hadjoudis E., Photochromic and thermochromic anils, Mol. Eng.,5, 301-337 (1995)
  9. Houlden SA, Csizmadia IG, The geometry and electronic structure of substituted Schiff's bases, Tetrahedron, 25,1137-1153 (1969)
  10. Guha D., Mandal A., Koll A., Filarowski A., Mukherjee S., Proton transfer reaction of a new orthohydroxy Schiff base in protic solvents at room temperature, Spectrochim. Acta A., 56, 2669-2677 (2000)
  11. Issa RM, El-Daly SA, El-Wakiel NA UV/Vis, IR and H NMR spectroscopic studies of bis azo-dianil compounds based on 5-(2- carboxyphenyl azo)-salicylaldehyde and primary diamines, Spectrochim. Acta A.,59, 723-728,(2003)
  12. Schiff W, Szady-Chelmieniecka A, Grech E, Przybylski P, Brzezinski B, Spectroscopic studies of new Schiff and Schiff–Mannich bases of ortho-derivatives of 4-Bromophenol, J. Mol. Struct., 643, 115-121, (2002)
  13. Prisakar VI, Tsapkov VI, Buracheeva SA, Byrke MS, Gulya AP, Synthesis and antimicrobial activity of coordination compounds of copper with substituted salicylaldehyde thiosemicarbazones, Pharm. Chem. J.,39,30-32, (2005)
  14. Pelttari E, Karhumaki E, Langshaw J, Perakyla H, Elo H, Antimicrobial properties of substituted salicylaldehyde and related compounds, Z. Naturforsch,62C, 487-497, (2007)
  15. Chohan ZH, Arif M, Sarfraz M,Metal-based antibacterial and antifungal amino acid derived Schiff bases: their synthesis, characterization and in-vitro biological activity, Appl. Organomet. Chem., 21, 294-302 (2007)
  16. Tsapkov VI, Prisacar VI, Buracheva SA, Lazakovich DV, Gulya AP, Synthesis and antimicrobial activity of sulfazine-containing copper(II) coordination compounds with substituted salicylaldehydebenzoylhydrazones, Pharm. Chem. J.,42, 523-526, (2008)
  17. Shi L, Ge HM, Tan SH, Li HQ, Song YC, Zhu HL, Tan RX, Synthesis and antimicrobial activity of Schiff bases derived from 5- chloro-salicylaldehyde, Eur. J. Med. Chem., 42, 558-564 (2007)
  18. Mims C., Dockrell H.M., Goering R.V., Roitt I., Wakelin D., Zuckerman M, Medical Microbiology, Elsevier Mosby, updated 3rd edition, 11-12 (2004)