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Synthesis and Antimicrobial studies of few New Substituted 2-methyl-3-(aryldiazenyl)pyrazolo[5,1-b]quinazolin-9(3H)-ones

Author Affiliations

  • 1S.S.G.M. College, Loha, Nanded, INDIA
  • 2 Department of Chemistry and Research Center, N.S. B. College Nanded, INDIA

Res.J.chem.sci., Volume 3, Issue (6), Pages 60-68, June,18 (2013)

Abstract

Synthesis of substituted 2-methyl-3-(aryldiazenyl)pyrazolo[5,1-b]quinazolin-9(3H)ones [4a-4t] is carried out by coupling of diazonium salts of aromatic amines [3a-3d] with 2-methylpyrazolo[5,1-b]quinazolin-9(4H)-ones [2a-2e]. The structures of compounds [4a-4t] are confirmed by IR and 1HNMR, 13CNMR and mass spectral studies. Further, they were screened in vitro for antibacterial activity against Escherichia coli and Salmonella typhi. Antifungal activity is evaluated against Aspergillus niger and Penicillium chrysogenum using Paper disc diffusion method. Few compounds have shown potential antibacterial and antifungal activities.

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