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A Facile Route for the Preparation of Phosphonic Acid Grafted Nanosized Hydroxyapatite Biomaterial

Author Affiliations

  • 1Department of Chemistry, National Institute of Technology, Arunachal Pradesh, INDIA
  • 2Department of Chemistry, Indian Institute of Technology, Kharagpur-721302, INDIA

Res.J.chem.sci., Volume 3, Issue (4), Pages 78-80, April,18 (2013)


The present research effort consists in the development of phosphonic acid grafted nanosized hydroxyapatite (n-HAp) through a straightforward chemical methodology. Fourier transform infrared absorption spectroscopy (FTIR) and electron diffraction X-ray (EDX) studies show the stoichiometric creation of HAp particles. The existence of phosphonic acid on the hydroxyapatite particle surface was investigated through FTIR study also. Transmission electron microscopy (TEM) analysis divulges needle like acicular crystals of HAp particles with inexact size of 25-33 nm in diameter by 70-85 nm in length. The prepared hydroxyapatite material may be used in building a biocomposite with high interfacial bonding.


  1. Hench L.L., Bioceramics, J. Am. Ceram. Soc.,81, 1705 (1998)
  2. Bacon G.E., Bacon P.J. and Griffiths R.K., Neutron diffraction studies of lumbar vertebrae, J. Anat.,128, 277 (1979)
  3. Sinha A., Nayar S., Agrawal A., Bhattacharyya D. and Ramachandrarao P., Synthesis of nanosized and Microporous precipitated Hydroxyappatite in synthetic polymers and Biopolymers, J. Am. Ceram. Soc., 86, 357 (2003)
  4. Mishra D.N., Adsorption of Low-molecular-weight Sodium Polyacrylate on Hydroxyapatite, J. Dent. Res.,64, 1405 (1985)
  5. Liu Q., De Wijn J.R., Bakker D., Van Toledo M. and Van Blitterswijk C.A., An introduction to materials and medicine, J. Mater. Sci.: Mater. Med., 23 (1998)
  6. Liu Q., De Wijn J.R. and Van Blitterswijk C.A., A study on the grafting reaction of isocyanates with hydroxyapatite particles, J. Biomed. Mater. Res.,40, 358 (1998)
  7. Abboud M., Turner M., Duguet E. and Fontanille M., PMMA based composite materials with reactive ceramic fillers. Part 1–Chemical modification and characterisation of ceramic particles, J. Mater. Chem.,7, 1527 (1997)
  8. Greish Y.E. and Brown P.W., Preparation and characterization of calcium phosphate-poly(vinyl phosphonic acid) composites, J. Mater. Sci.: Mater. Med.,12, 407 (2001)
  9. Mou L., Singh G. and Nicholson J.W., Synthesis of a hydrophilic phosphonic acid monomer for dental materials, Chem. Commun.,5, 345 (2000)
  10. Landi E., Tampieri A., Celotti G. and Sprio S., Densification Behavior and Mechanisms of Synthetic Hydroxyapatites, J. Eur. Ceram. Soc.,20, 2377 (2000)
  11. Dorozhkin S.V. and Epple M., Biological and Medical Significance of Calcium Phosphates, Angew. Chem.,41,3130 (2002)
  12. Pramanik N., Bhargava P., Alam S. and Pramanik P.,Processing and Properties of Nano- and Macro- Hydroxyapatite/ Poly(ethylene-co-acrylic acid) Composite, Polym. Compos.,27, 633 (2006)