International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis and Antimicrobial screening of Chalcones containing imidazo [1,2-a] pyridine nucleus

Author Affiliations

  • 1Department of Chemistry, Arts, Science and Commerce College, Naldurg, Tq-Tuljapur, Dist.-Osmanabad-413 602, Maharashtra, INDIA,

Res.J.chem.sci., Volume 3, Issue (12), Pages 38-42, December,18 (2013)

Abstract

A series of chalcones were prepared by reacting various acetophenones with 2-(4-bromophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde in the presence of alcoholic alkali. The structures of these compounds were confirmed on the basis of spectral data. All the title compounds were screened for their antimicrobial activities. The screening data indicated that tested compounds showed good antimicrobial activity.

References

  1. Hanson S.M., Morlock E.V., Satyshur K.A., Czajkowski C. Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different, J. Med. Chem., 51(22), 7243-52 (2008)
  2. Mavel S., Renou J.L., Galtier C., Snoeck R., Andrei G., Balzarini J., De Clercq E. and Gueiffier A., One-pot Synthesis of 3-Aminoimidazo[1,2-]pyridines Catalyzed by Heteropolyacids, Arzneim.-Forsch, 51, 304 (2001)
  3. Lacerda R.B., De Lima C.K., Da Silva L.L., Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes.Bioorg. Med. Chem. Lett., 17, 74 (2009)
  4. Bhale P.S. and Dongare S.B., Synthesis and antimicrobial screening of Mannich bases of imidazo[1,2-a] pyridine, Golden Research Thoughts, 2, 1-6, 2013 (b) Bhale, P. S.; Dongare, S. B., Synthesis and antimicrobial screening of Schiff’s bases of imidazo [1,2-a] pyridine Int. J. Chem. Sci., 11, 1563 (2013)
  5. Humphries A.C., Gancia E., Gilligan M.T., Goodacre S., Hallett D., Marchant K.J. and Thomas S.R., 8-Fluoroimidazo [1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor, Bioorg. Med. Chem. Lett. 16, 1518 (2006)
  6. Dvey D., Erhardt P.W., Lumma W.C., Jr.; Wiggins, J.; Sullivan, M.; Pang, D.; Cantor, E., Novel 8-aryl-substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo [1,5-a] pyridinones as potential positive inotropic agents, J. Med. Chem., 30, 1337 (1987)
  7. Langer S.Z., Arbilla S.; Benavides, Zolpidem and alpidem: two imidazopyridines with selectivity for omega 1- and omega 3-receptor subtypes, J. Adv. Biochem. Psychopharmacol., 46, 61 (1990)
  8. Harrison T.S., Keating G.M., Zolpidem: a review of its use in the management of insomniaCNS Drugs 19, 65 (2005)
  9. Ueda T., Mizusgige K., Yukiiri K. and Takahashi T., Cerebrovasc. Dis., Synthesis and antimicrobial screening of Mannich bases of imidazo[1,2-a] pyridine, 16, 396, (2003)
  10. Douhal A. Ber. Bunsen-Ges., The involvement of rotational processes in the intramolecular proton-transfer cycle, Phys. Chem., 102, 448, (1998)
  11. Haefely W., Martin J.R., Schoch P., Novel anxiolytics that act as partial agonists at benzodiazepine receptorsTrends Pharmacol. Sci., 11, 452 (1990)
  12. Tomczuk B.E., Taylor C.R., Moses L.M., Sutherland D.B., Lo Y.S., Johnson D.N., Kinnier W. B., Kilpatrick, B. F., 2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics, J. Med. Chem, 34, 2993 (1991)
  13. Denora N., Laquintana V., Pisu M.G., Dore R., Murru L., Latrofa A. and Trapani G., Sanna, 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies, E. J. Med. Chem., 51, 6876 (2008)
  14. Al-Tel T.H., Al-Qawasmeh R.A. and Zaarour R., Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs, Eur. J. Med. Chem., 46, 1874 (2011)
  15. Rupert K.C., Henry J.R., Dodd J.H., Wadsworth S.A., Cavender D.E., Olini G.C., Fahmy B. and Siekierka J., J. Bioorg. Med. Chem. Lett., 13, 347 (2003)
  16. Gudmundsson K.S., Johns B.A., Imidazo[1,2-a]pyridines with potent activity against herpesviruses, Bioorg. Med. Chem. Lett. 17, 2735 (2007)
  17. Kenda B.M., Matagne A.C., Talaga P.E., Pasau P.E., Differding E., Lallemand B.I., Frycia A.M., Moureau F. G., Klitgaard H.V., Gillard M.R., Fuks B., Michel P., Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity, J. Med. Chem., 47, 530 (2004)
  18. Gudmundsson K.S., Boggs S.D., Catalano J.G., Svolto A., Spaltenstein, A., Thomson M., Wheelan P. and Jenkinson S.,\Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1., Bioorg. Med. Chem. Lett., 19, 6399 (2009)
  19. Baviskar A.T.; Madaan C., Preet R., Mohapatra P., Jain V., Agarwal A., Guchhait S.K., Kundu C.N., Banerjee U.C., Bharatam P.V., N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIand induce apoptosis in G1/S phase, J. Med. Chem., 54, 5013 (2011)