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Synthesis and Characterization of a New Series of2-(5-bromothiophen-2-yl)-5-Substituted-1, 3, 4-Oxadiazoles

Author Affiliations

  • 1Department of Chemistry, Manipal Institute of Technolgy, Manipal University, Manipal-576014, Karnataka, INDIA

Res.J.chem.sci., Volume 3, Issue (10), Pages 51-55, October,18 (2013)



  1. Patel N.B. and Patel J.C., Synthesis and antimicrobial activity of 3-(1, 3, 4-oxadiazol-2-il)quinazolin-4(3H)-ones, Sci. Pharm., 78, 171–193(2010)
  2. Sangshetti J.N., Chabukswar A.R. and Shinde D.B., Microwave assisted one pot synthesis of someNovel 2, 5- disubstituted 1, 3, 4-oxadiazoles as antifungal agents, Bioorg. Med. Chem. Lett., 21, 444–448(2011)
  3. Husain A., Ahmad A., Alam M.M., Ajmal M. and Ahuja P., Fenbufen based 3-[5-(substitutedaryl)-1, 3, 4-oxadiazol- 2-yl)]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents, Eur. J. Med. Chem., 44, 3798–3804(2009)
  4. Manjunatha K., Poojary B., Lobo P.L., Fernandes J. and Kumari N.S., Synthesis and biologicalevaluation of some 1, 3, 4-oxadiazole derivatives, Eur. J. Med. Chem. 45, 5225– 5233(2010)
  5. Amir M. and Kumar S., Synthesis and evaluation of antiinflammatory, analgesic ulcerogenic andlipid peroxidation properties of ibuprofen derivatives, Acta Pharm., 57, 31–45 (2007)
  6. Kashaw S.K., Gupta V., Kashaw V. and Mishra P. et al., Anticonvulsant andsedative-hypnotic activity of some novel 3-[5-(4-substituted) phenyl-1, 3, 4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones, Med. Chem. Res, 19, 250– 261(2010)
  7. Rajak H., Deshmukh R., Veerasamy R., Sharma A.K., Mishra, P. et al., Novelsemicarbazones based 2, 5- disubstituted-1, 3, 4-oxadiazoles: One more step towards establishingfour binding site pharmacophoric model hypothesis for anticonvulsant activity, Bioorg. Med.Chem. Lett., 20, 4168–4172 (2010)
  8. Xiumian Z., Zhong L., Yanli W., Weidong C., et al., Syntheses and insecticidal activities of novel 2, 5 disubstituted 1, 3, 4-oxadiazoles, J. Fluorine Chem., 123(2), 163-169 (2003)
  9. Almasirad A., Vousooghi N., Tabatabai S.A., Kebriaeezadeh A. et al., Synthesis, Anticonvulsant and Muscle Relaxant Activities of Substituted 1, 3, 4- oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole, Acta Chimica Slovenica, 54 ( 2), 317(2007)
  10. Cledualdo S., Bruno F. L., Jose Maria B., Jorge G. F. L. and Petronio F., Synthetic Approaches and Pharmacological Activity of1, 3, 4-Oxadiazoles: A Review of the Literature from 2000–2012, Molecules, 17, 10192- 10231(2012)
  11. Li X. and He D., Synthesis and optical properties of novel anthracene-based stilbene derivativescontaining an 1, 3, 4- oxadiazole unit, Dyes Pigm., 93, 1422–1427 (2012)
  12. Gaonkar S. L., Lokanatha Rai K.M. and Prabhuswamy B., Synthesis and anti-microbial studies of a new series of 2- {4-[2-(5-ethylpyridin-2-ylethoxy] phenyl}-5-substituted-1, 3, 4-oxadiazoles, Eur. J. Med. Chem., 41, 841(2006)
  13. Gaonkar S. L., Mahendra M., Nanjunda Swamy S. and Shetty Nitinkumar S., Synthesis and Crystal structure studies of Diethyl-(6-chloro-2-carbazolyl) Methyl malonatean intermediate in the synthesis of Antiinflammatory drug Carprofen, Res. J. Pharmaceutical Sci, 1(1), 16-22 (2012)
  14. Kumar A., D’Souza S.S., Mysore Nagaraj S.R., Gaonkar S.L., Salimath B.P. and Rai K.M.L., Antiangiogenic and antiproliferative effects of substituted-1, 3, 4-oxadiazole derivatives is mediated by down regulation of VEGF and inhibition of translocation of HIF-1a in Ehrlich ascites tumor cells, Cancer chemotherapy and pharmacology, 64 (6), 1221-1233 (2009)
  15. Gaonkar S.L. and Rai K.M.L., A new method for the generation of azoalkenes from ketohydrazones and its application to the synthesis of tetrahydropyridazine derivatives, Tetrahedron letters, 46 (35), 5969-5970 (2005)