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Biochemical Studies of Autism Spectrum Disorder Patients in Mosul City

Author Affiliations

  • 1Chemistry Dept. Science College- Mosul University, IRAQ
  • 2Physiology Dept.Veterinary College- Mosul University, IRAQ

Res.J.chem.sci., Volume 3, Issue (10), Pages 8-15, October,18 (2013)

Abstract

Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder. It includes five diagnostic subtypes. The currentstudy was carried out among 2-12 years old children with ASD. Thirty seven subjected to ASD (31males and 6 females) wereselected from psychiatric research unit -Mosul University. Thirty healthy children were enrolled in this study (20 males and10 females) with the same age as control group. ASD patients were classified into three groups according to symptomsseverity grade. The results indicated a significant (p≤=0.05) decrease in the serum melatonin (-81.8%), neuroglobin (-84.9%),antioxidant activity (-69.8%) and glutathione (-63.3%) in severe ASD group compared to control group. At the same time asignificant (p≤=0.05) increase in the serum thiobarbituric acid reactive substances (+82.6%), advanced oxidation proteinproducts (+120.6%) and nitric oxide (+85.5%) in severe ASD patients group compared to control group were observed.Also, a positive significant (p≤=0.01) correlation between antioxidant activity and melatonin, neuroglobin, glutathione wasshown, while a negative significant (p≤=0.01) correlation between antioxidant activity and thiobarbituric acid reactivesubstances, advanced oxidative protein products and nitric oxide was indicated in the current study.

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