In-vitro Antioxidant activity of Diethyl malonate adducts of Phenothiazine

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In-vitro Antioxidant activity of Diethyl malonate adducts of Phenothiazine

Author Affiliations

¹Department of Chemistry, Karpagam University, Coimbatore 641021, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 3, Issue (1), Pages 82-85, January,18 (2013)

Abstract

A series of novel diethyl malonate adducts 2a-g was prepared by the condensation between chalcones 1a-g and diethyl malonate in presence of KOt-Bu. The products were characterized by their spectral data (UV, IR, NMR and elemental analysis). In-vitro antioxidant activity was carried out for 2a-g which showed good anti-oxidant activity with IC50 value between 36.15 to 81.00痢/ml and comparable to the control quercetin with IC50 value 44.53(痢/ml). Compound 2a and 2d showed higher activity with IC50 value of 39.13 and 36.1痢/ml respectively

References

House H.O., Modern Synthetic reactions, 2nd ed., BenjaminW A., Inc., New York., 595, (1972)
Dae Young Kim, Sun Chul Huh. and Sung Min Kim.,Enantioselective Michael reaction of malonates andchalcones by phase transfer catalysis using chiralquarternary ammonium salt, Tetrahedron Letters., 42,6299-6301 (2001)
Yakup Budak., Burcu Gurdere M., Meryem Kececi. andMustafa Ceylon., Preparation of diethylmalonate adductsfrom chalcone analogs containing thienyl ring, Bull. Chem.Soc. Ethiopia., 24(1), 85 (2010)
Hai-Bo Shi., Shi-Ji Zhang., Qiu-Fu Ge., Dian-Wuo., ChaoMingCai. and Wei-Xao Hu., Synthesis and anticancerevaluation of thiazolyl-chalcones, Bioorganic andMedicinal Chemistry Letters., 20, 6555- 65 (2010)
Jignesh P Raval. and Kishor R Desai., Synthesis andantimicrobial activity of new triazolopyridinylphenothiazines, ARKIVOC., xiii, 21-28 (2005)
Gunars Tirtis and Grzegorz Bartosz., Determination ofantiradical and antioxidant activity: basic principles andnew insights, Biochimica Polonica., 57, 139-142 (2010)
Sawney S.N., Dhindsa G.S. and Dharam Vir., Synthesis ofsome 2-heterocyclylphenothiazines as potential antiinflammatoryagents, J of Indian Chem Society., LXV, 643-647 (1988)
Gopalakrishnan M., Thanusu J., Kanagarajan V. andGovindaraju R., Synthesis, antibacterial and antifungalactivities of biolabile (E)-1-(4-morpholinophenyl)-3-arylprop-2-en-1-ones,Med Chem Res., 18, 341-350 (2009)
Tandel R.C., Gohil Jayvirsinth. and Patel Nileshk.,Synthesis and study of main chalcone polymers exhibitingnematic places, Research Journal of Recent Sciences.,1,122-127 (2012)
Sathish Kumar T., Shanmugam S., Palvannan T. andBharathi Kumar V.M., Evaluation of Antioxidant Propertiesof Elaeocarpus ganitrus Roxb. Leaves, Iranian Journal ofPharmaceutical Research., 7 (3), 211-212 (2008)

[ref1] House H.O., Modern Synthetic reactions, 2nd ed., BenjaminW A., Inc., New York., 595, (1972)

[ref2] Dae Young Kim, Sun Chul Huh. and Sung Min Kim.,Enantioselective Michael reaction of malonates andchalcones by phase transfer catalysis using chiralquarternary ammonium salt, Tetrahedron Letters., 42,6299-6301 (2001)

[ref3] Yakup Budak., Burcu Gurdere M., Meryem Kececi. andMustafa Ceylon., Preparation of diethylmalonate adductsfrom chalcone analogs containing thienyl ring, Bull. Chem.Soc. Ethiopia., 24(1), 85 (2010)

[ref4] Hai-Bo Shi., Shi-Ji Zhang., Qiu-Fu Ge., Dian-Wuo., ChaoMingCai. and Wei-Xao Hu., Synthesis and anticancerevaluation of thiazolyl-chalcones, Bioorganic andMedicinal Chemistry Letters., 20, 6555- 65 (2010)

[ref5] Jignesh P Raval. and Kishor R Desai., Synthesis andantimicrobial activity of new triazolopyridinylphenothiazines, ARKIVOC., xiii, 21-28 (2005)

[ref6] Gunars Tirtis and Grzegorz Bartosz., Determination ofantiradical and antioxidant activity: basic principles andnew insights, Biochimica Polonica., 57, 139-142 (2010)

[ref7] Sawney S.N., Dhindsa G.S. and Dharam Vir., Synthesis ofsome 2-heterocyclylphenothiazines as potential antiinflammatoryagents, J of Indian Chem Society., LXV, 643-647 (1988)

[ref8] Gopalakrishnan M., Thanusu J., Kanagarajan V. andGovindaraju R., Synthesis, antibacterial and antifungalactivities of biolabile (E)-1-(4-morpholinophenyl)-3-arylprop-2-en-1-ones,Med Chem Res., 18, 341-350 (2009)

[ref9] Tandel R.C., Gohil Jayvirsinth. and Patel Nileshk.,Synthesis and study of main chalcone polymers exhibitingnematic places, Research Journal of Recent Sciences.,1,122-127 (2012)

[ref10] Sathish Kumar T., Shanmugam S., Palvannan T. andBharathi Kumar V.M., Evaluation of Antioxidant Propertiesof Elaeocarpus ganitrus Roxb. Leaves, Iranian Journal ofPharmaceutical Research., 7 (3), 211-212 (2008)