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Synthesis and Antimicrobial Activity of Azetidin-2-one Containing Pyrazoline Derivatives

Author Affiliations

  • 1Dept. of Chem., Patel JBR Arts, Patel AMR Commerce and Patel JDKD Science College, Borsad, GJ, & JJT-University, RJ, INDIA
  • 2Department of Chemistry, Sheth LH Science College, Mansa, Gujarat, INDIA

Res.J.chem.sci., Volume 2, Issue (7), Pages 62-68, July,18 (2012)

Abstract

Pyrazolines are well-known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. A new series of 3-chloro-1-{4-[5-(Substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-4-(4-hydroxyphenyl) azetidin-2-one are synthesized by reacting 3-chloro-1-{4-[3-(Substituted phenyl)prop-2-enoyl]phenyl}-4-(4-hydroxyphenyl)azetidin-2-one with 99% hydrazine hydrate. All these compounds were characterized by means of their IR, 1H NMR, Spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.

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