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Microwave Assisted Synthesis, Characterization and Antibacterial Activity of Some Arsenic (III) Derivatives of O-Alkyl or O-Aryl Trithiophosphates

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Author Affiliations

  • 1Synthetic and Surface Science Laboratory, Dept. of Chemistry, Govt. College, Ajmer (Raj.) 305001, INDIA

Res.J.chem.sci., Volume 2, Issue (5), Pages 57-65, May,18 (2012)

Abstract

Arsenic (III) O-alkyl or O-aryl trithiophosphate of the type ClAs[S2(S)P(OR)] and ROP(S)[SAsS2P(S)OR)]2 (R=Me, Et, Pri, Bui, Ph, CH2Ph) have been synthesized by solvent free microwave assisted procedure from the reaction of arsenic trichloride with potassium salts of O-alky1 or O-aryl trithiophosphate in 1:1 and 2:3 motar ratio respectively. These derivatives have been characterized by elemental analysis, molecular weight determinations and spectroscopic (IR, 1H and 31P NMR) studies. On the basis of them distorted tetrahedral geometry has been proposed for these derivatives. The newly synthesized derivatives show good activity against gram positive and gram negative bacteria and a comparative study of antibacterial effect has also been made with standard drugs.

References

  1. Chaturvedi A., Nagar P.N. and Srivastava G., Synthese and Spectroscopic Studies of 2-Alkylene Dithiophosphato-13,2-Dioxarsolanes and Arsenanes, Phosphorous, Sulfur and Silicon, 80, 141 (1993)
  2. Chaturvedi A., Nagar P.N. and Srivastava G., Synthesis and Properties of Mixed ligand Complexes of Diorganotin (IV) Part II; Acetato Diorgaoti β-Diketonates and 1-acetato-3-β-Diketonato Tetraorgano Distannoxanes, Main Group Met.Chem., 16, 1 (1993)
  3. Chaturvedi A., Nagar P.N. and Srivastava G., Synthesis and Properties of Mixed ligand Complexes of Diorganotin (IV) Part III; β- diketonato Diorganotin Alkylene Dithiophosphate, Main Group Met.Chem., 16, 45 (1993)
  4. Chaturvedi A., Nagar P.N. and Rai A.K., Cleavage Reactions of Triphenyl Antimony With Dialkyl (or alkylenyl) Dithiophosphoric Acids, Synth. React. Inorg. Met. Org. Chem., 26, 1025-1033 (1996)
  5. Chaturvedi A., Sharma R.K., Nagar P.N. and Rai A.K., Syntheses and Spectroscopic Studies of Diorganotin Bis-O-Alkyl Phosphonates, Phosphorous, Sulfur and Silicon., 112, 179-183 (1996)
  6. Chauhan H.P.S., Bhasin C.P., Srivastava G. and Mehrotra R.C., Synthesis and Characterization of 2-Mercapto-2-Thiono-1,3,2-Dioxaphospholanes and Dioxaphosphorinanes, Phosphorous, Sulfur and Silicon.,15, 99-104, (1983)
  7. Tripathi U.N., Sharma D.K., Jain N. and Soni H., Synthesis and Characterization of Tin (IV) trithiophosphates and their Adducts with nitrogen Donar Bases, Phosphorous, Sulfur and Silicon,182 (7), 1033 (2007)
  8. Tripathi U.N. and Ahmed Mohd., Synthesis and Characterization of Triphenyleantimony (V) ( O-Alkyl, O-Cycloalkyl Phosphorou and O-Aryltrithiophosphates), Sulfur and Silicon, 179, 2307-2313 (2004)
  9. Krzyzanowska B. and Stec. W.J., New p-Chiral phosphates, phosphorothioates and Phosphoroselenothioates, Phosphorous & Sulfur, 30 (1-2), 287-292, (1987), Chem. Abstr., 108, 131929F (1988)
  10. Habig C., G. DJ and Richard T., The anticholinesterase effect of the cotton Defoliant S,S,S –tri-nbutyl Phosphorotrithioate(DEF) on Channel Catfish, Mar. Environ. Res. 24 (1-4), 193-197, (1988) Chem. Abstr. 109, 49948V (1988)
  11. Shahzad S., Shafrid K., Mazhar S.Ai.M. and Khan K.M., Organotin(IV) derivatives as Biocides: An Investigation of Structure by Ir, Solution NMR, Electron Impact MS and Assessment of Structure Correlation with Biocidal Activity, J. Iran. Chem. Soc., 2 (4), 277-288 (2005)
  12. Chordia L. and Chaturvedi A., Synthesis and Properties of Mixed Ligand Complexes of Diorganotin(IV): Part (V): Synthesis and Characterisation of Antifungal Acetylacetonato Diorganotin (IV)-O-Alkyl Trithiophosphates, Phosphorous, Sulfur and Silicon, 182, 2821 (2007)
  13. Chordia L. and Chaturvedi A., Synthesis and Properties of Mixed Ligand Complexes of Diorganotin: Synthesis and Characterisation of Antibacterial Benzoylacetonato Diorganotin (IV)-O-Alkyl Trithiophosphates, Main Group Met. Chem. 31 (6), 319 (2007)
  14. 2000 Emergency Response Guide Book Guide 157 (ERG 2000)
  15. Kamsonlian S., Balomajumder C., Chand S., Removal of As(III) from Aqueous Solution by Biosorption onto maize (Zea Mays) Leaves Surface; Parameters Optimization Sorption Isothermal, Kinetic and Thermodynamic Studies., Res. J. Chem. Sci. 1(5), 73-79 (2011)
  16. Sunil A., Raos J., Eco-Friendly approach for a facile Synthesis of O-hydroxyphenylthiourea and Its Property as an Analytical Reagent in Sensing Mercury(II), Res. J. Chem. Sci., 2(3), 30-40 (2012)
  17. Prado – Gonjal J., Villafuevte C., Fuentes L. and Moran E., microwave Hydrothermal Synthesis of BiFeO3, Mat. Res. Ball., 44, 1734-1737 (2009)
  18. Rao K.J., Vaidhyanathan B., Ganduli M., Ramakrishnan P.A., Synthesis of Inorganic Solids Using Microwaves, Chem. Mater., 11, 882-895 (1999)
  19. Vogel A.I.¸ ″A Text Book of Quantitative Inorganic Analysis″ Longman E.L.B.S. IV Edition (1973)
  20. Chauhan H.P.S., Srivastava G. and Mehrotra R.C., Alkylenedithiophosphate Derivatives of Arsenic (III), Antimony and Bismuth, Polyhedron. 3, 1337-1345 (1984)
  21. Chauhan H.P.S., Srivastava G. and Mehrotra R.C., Synthesis and Characterization of Dialkyldithiophosphate Derivatives of Arsenic(III), Synth. React. Inorg. Met. Org. Chem. 11, 565-575 (1981)
  22. Corbridge D.E.C., Phosphorus, an Outline of its Chemistry, Biochemistry and Uses, Top. Phosphorus Chem., 6, 235 (1669)
  23. Tripathi U.N., Vanubabu G., Mohd. Safi Ahmad, Rao Kolisetly S.S. and Srivastava, A.K., Synthesis, Spectral and Antimicrobial Studies of Diorganotin (IV) 3(2- hydroxyl Phenyl)-5(4-Substituted Phenyl) Pyrazolinates, J.Appl. Organomet. Chem., 20(10), 669-676 (2006)
  24. Tripathi U.N., Solanki Jeevan S., Bhardwaj A. and Thapak T.R., Synthesis, Spectral Study and Antimicrobial Activity Of Bismuth (III) 3(2-hydroxyphenyl-5-(4-Substituted Phenyl) Pyrazolinates, J. Coord. Chem. 61(24), 4025-4032 (2008)
  25. Silverstein R.M.¸ Webster F.X. ″Spectrometric identification of Organic Compounds″ 6th edition, John Wiley & Sons Inc., New York, (1998)