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Synthesis, Structure and Antimicrobial Activity of new 3- and 2- arylmethyl and arylacyl-3H[1,2,4]triazino[3,2-b]-quinazoline-2,6(1H)diones as expected as DNA fluorphores

Author Affiliations

  • 1Department of Chemistry, Faculty of Science (Girls), Taif University, 58- Taif, SAUDI ARABIA
  • 2 Dept. of Chem., Faculty of Science, Taif University,888-Taif, SAUDI ARABIA and Department of Chemistry, Cairo University, Giza, EGYPT

Res.J.chem.sci., Volume 2, Issue (5), Pages 23-28, May,18 (2012)


Starting from 2,3-diaminoquinazoline 3, a series of two isomers of new expected fluorescent 3- and 2-arylmethyl and arylacyl-3H[1,2,4]triazino[3,2-b]quinazoline-2,6(1H)diones 6 and 7 have been synthesized via its condensation with each of aryl pyruvic acid 4 and ethyl aroylpyruvates 5 depending upon the pH of the reaction medium. The structure of products was elucidated on the basis of their spectral, elemental analyses and alternate synthesis. The products 6 and 7 obtained are tested for antimicrobial activity and reported.


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