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Synthesis, Antibacterial and Antifungal Activities of some new Bipyrazolic Tripodal Derivatives

Author Affiliations

  • 1Laboratoire de Chimie Organique, Macromoléculaire et Produits Naturels (URAC 25), Facultés des Sciences, Oujda, MOROCCO
  • 2 Laboratoire de Biochimie, Département de Biologie, Facultés des Sciences, Oujda, MOROCCO

Res.J.chem.sci., Volume 2, Issue (4), Pages 40-44, April,18 (2012)


A series of novel bipyrazolic tripodal derivatives were prepared in one step, in good and excellent yields. The in vitro antibacterial and antifungal activities of these products and their starting materials were screened against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). Structure-activity relationship (SAR) reflects the effect of substituted drugs. A considerable activity was recorded with respect to the Fusarium oxysporum f.sp albedinis with MIC = 7,05.


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