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Effect of Dietary Vitamin A Supplement on Serum Protein of Rats Infected with Trypanosoma brucei

Author Affiliations

  • 1Nnamdi Azikiwe University Awka, Anambra State, NIGERIA
  • 2 Federal University of Science and Technology Owerri, Imo State, NIGERIA

Res.J.chem.sci., Volume 2, Issue (11), Pages 61-63, November,18 (2012)


The role of dietary vitamin A supplement on the serum protein of trypanosome-infected rats was studied. The rats were inoculated with trypanosomes intraperitoneally and samples were collected on fourth, eight, twelfth and sixteenth days of post infection. The experiment was carried out at the Department of Biochemistry, Nnamdi Azikiwe University Awka. 60 parasite free-albino rats were used, which were divided into four groups. Group A (control) was left uninfected with trypanosomes, group B and C were infected with trypanosomes and treated with 50mls and 100mls of vitamin A per kg of feed respectively and group D was infected and left untreated with vitamin A. Analyses of the sera using Bradford method and cellulose acetate electrophoresis showed that vitamin A influenced the state of hypoproteinaemia in the trypanosome-infected rats. This was manifested by a positive increase in the level of total serum protein concentration, albumin and beta-globulin. Vitamin A also delayed the proliferation of the parasites associated with trypanosomiasis.


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