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Oxidation of Flavoxate by Chloramine-T in HCl Medium, a Kinetic and Mechanistic Approach

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Author Affiliations

  • 1Department of Chemistry, Jyoti Nivas College Autonomous, Koramangala, Bangalore-560095, Karnataka, INDIA
  • 2 Department of Chemistry, East Point College of Engineering and Technology, Bidarahalli, Bangalore, Karnataka, INDIA

Res.J.chem.sci., Volume 2, Issue (10), Pages 64-69, October,18 (2012)

Abstract

The kinetics of oxidation of flavoxate (FX) by sodium-N-chloro-p-toluenesuphonamide or chloramine-T (CAT) has been carried out in acid medium at 303K. The reaction rate shows a first order dependence on [oxidant], fractional order on [substrate]and an inverse fractional order on [H+]. The addition of the reaction product (p-toluenesulphonamide) and halide ions have no significant effect on the rate of the reaction. The variation of ionic strength of the medium did not affect the rate, indicating that non ionic species are involved in the rate determining step. The dielectric effect is negative. The reaction fails to initiate the polymerization of acrlyamide. Thermodynamic parameters were computed by studying the reaction at different temperatures. The reaction stoichiometry and oxidation products were identified. Activation parameters for the rate-limiting step have been computed. Based on the experimental observations a suitable mechanism was proposed and rate law deduced.

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