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Facile and Stereoselective Synthesis of Novel trans-3-Monosubstituted-3-benzylseleno-B-lactams lactams

Author Affiliations

  • 1Department of Chemistry & Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh-160014, INDIA

Res.J.chem.sci., Volume 2, Issue (1), Pages 59-64, January,18 (2012)


A facile and stereoselective synthesis of novel trans-3-monosubstituted-3-benzylseleno-β -lactams () via Lewis acid mediated functionalization of -lactam carbocation equivalents () with active aromatic and heterocyclic compounds (nucleophiles) is described. The structures of these novels -lactams have been established on the basis of spectroscopic studies (FTIR, 1H NMR, 13C NMR, 77Se NMR, GCMS) and elemental analysis. The cis or trans configuration of the hydrogen/chloro /nucleophile substitutent at C-3 was assigned with respect to C4-H.


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