International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis and complexation of bis(thiourea) with Co(II) and Cu(II) ions

    , ,

Author Affiliations

  • 1Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria
  • 2Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria
  • 3Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria

Res.J.chem.sci., Volume 12, Issue (1), Pages 58-63, February,18 (2022)

Abstract

Bis(thiourea) was synthesized from reaction of semicarbazide hydrochloride and potassium thiocyanate in 1:1 molar ratio in aqueous medium. Interaction of the bis(thiourea) with chloride salts of cobalt(II) and copper(II) yielded the respective complexes of varying colours in excellent yield of 74.52% and 64.81% respectively. The bis(thiourea) and its complexes were characterized using FT-IR spectroscopy and various physicochemical techniques. The ligand has sharp melting point of 217°C indicating its purity whereas the Co(II) and Cu(II) decomposed at 190 and 340°C respectively, suggestive of thermostability. The molar conductance measurement revealed that the Co(II) complex was electrolytic in nature while Cu(II) was non-electrolyte. The complexes were hydrated as revealed by thermal and FT-IR analysis. Moreover, the results of FT-IR affirmed the coordination of the metal(II) ions to the bis(thiourea) through the two thionic Sulphur atoms (>C=S) hence acting as a bidentate ligand. On the basis of the spectral analysis, the complexes could be formulated as [CoL2]Cl2.H2O and [CuL2(OH)2].3H2O where L=bis(thiourea).

References

  1. Sacht, C., Datt, M. S., Otto, S. and Roodt, R. (2000)., Chiral and Achiral Platinum (II) Complexes for Potential Use as Chemotherapeutic agents: Crystal and Molecular Structures of cis-[Pt(L1)2] and [Pt(L1)Cl(MPSO)] [HL1=N,N-diethyl-N’-benzoylthiourea]., Journal of Chemical Society, Dalton Transactions, 5, 727-733. https://doi.org/10.1039/A908985C
  2. Henderson, W., Nicholson, B. K., Dinger, M. B. and Bennett, R. L. (2002)., Thiourea Monoanion and Dianion Complexes of Rhodium(III) and Ruthenium., Inorganica Chimica Acta, 338, 210-2018.
  3. Carcu, V., Negoiu, M., Rosu, T. and Serban, S. (2000)., Synthesis, Characterization of Complexes of N-benzoyl-N’-2-nitro-4-methoxyphenylthiourea with Cu, Ni, Pt, Pd, Cd and Hg., Journal of Thermal Analytical Calorimetry, 61(3), 935-945.
  4. Arslan, H., Florke, U. and Kulcu, N. (2004)., The Crystal and Molecular Structure of 1-(Biphenyl-4-carbonyl)-3-p-Tolyl-thiourea., Acta Chim.Slov., 51, 787-792.
  5. Jurca B., Salageanu, I. and Segal, E. (2000)., Thermal and Kinetic Studies on the Stability of Some Ureido-sulfonamide Derivatives., Journal of Thermal Analytical Calorimetry, 62, 859-872.
  6. Slawiki, J. and Gdaniec, M. (2005)., Synthesis, Molecular Structure, and In vitro Antitumor Activity of New 4-Chloro-2-mercaptobenzenesulfonnamide derivatives., European Journal of Medicinal Chemistry, 40(4), 377-389.
  7. Gadad, A. K, Noolyi, M. N. and Karpoormath, R. V. (2004)., Synthesis and Anti-tubercular Activity of a Series of 2-sulfonamido/trifluoromethyl-6-Substituted Imidazo [2,1-b]-1,3,4-thiadiazole Derivatives., Bioorganic Medical Chemistry, 12, 5651–5659.
  8. Adedeji, J. F., Amolegbe, S. A., Adewuyi, S., Akinremi, C. A., Oyeniran, Y. C. and Afolayan, B. O (2013)., Ligation of Fe(III) and Mn(II) Complexes by Bithiourea and their Biological Activity., IRSN Inorganic Chemistry, 3 DOI:10.1155/2013/329508.10.
  9. Ibrahim, A. K, Yusuf, B.A. and Hamisu, A. (2017)., Synthesis, Characterization and Antimicrobial Studies of Cu(II) and Zn(II) Complexes with the Schiff Base N-Salicylidene-4-chloro aniline., Chemsearch Journal, 8(2), 68-74.
  10. Ahmed, A. A. and Aliyu, H. N. (2019)., Synthesis, Structural Characterization and Antimicrobial Potency of Anthranilic Acid Based Mn(II) Schiff Base Complex., Chemistry Research Journal, 4(5), 54-61.
  11. Yahaya, N. P. and Mukhtar, M. S. (2021)., Synthesis, Characterization and Antimicrobial Activity of Mixed Ligand of Schiff Base and its Metal(II) complexes Derived from Ampicilin, 3-aminophenol and Benzaldehyde., Science Journal of Chemistry, 9(1), 9-13. DOI:10.11648/j.sjc.20210901.12
  12. Kafi-Ahmadi, L., Marjani, A. P. and Pakdaman-Azari, M. (2018)., Synthesis, Characterization and Antibacterial Properties of N, N’-Bis (4-dimethylaminobenzylidene) benzene-1,3-diamine as New Schiff Base Ligand and its Binuclear Zn(II), Cd(II) Complexes., South African Journal of Chemistry, 71, 155-159. https://doi.org/10.17159/0379-4350/2018/v71a20
  13. Al-Amiery, A. A., Al-Majedy, Y. K., Abdulrazak, H. and Abood, H. (2011)., Synthesis, Characterization, Theoretical, Crystal Structure and Antibacterial Activities of some Transition Metal complexes of the Thiosemicarbazone (Z)-2-(pyrrolidine-2-ylidiene) hydrazine carbothioamide., Bioinorganic Chemistry and Applications, 1-6. DOI:10.1155/2011.483101.
  14. Rizwana, B. and Lakshmi, S. S. (2012)., Synthesis, Characterization and Antimicrobial Studies of Zn(II), Ni(II) and Cu(II) complexes of a Schiff Base Derived From o-vanillin and N-allylthiourea., International Journal of Chem Tech Research, 4(1), 464-473.
  15. Chah, C. K., Ravoof, T. B. S. A. and Veerakumarasivam, A. (2018)., Synthesis, Characterization and Biological Activities of Ru(II), Mo(IV), Cd(II), Zn(II) and Cu(II) Complexes Containing a Novel Nitrogen-sulphur Macrocyclic Schiff Base Derived from Glyoxal., Science and Technology, 26(2), 653-670.
  16. Islam, S., Siddiki, A. K. M. N., Begum, S. and Abdussalam, M. (2018)., Synthesis, Spectral Characterization and Thermal Behaviour of Newly Derived La(III), Co(III) and Mn(II) Complexes with Schiff base derived from Methionine and salicylaldehyde., Open Journal of Inorganic Chemistry, 8, 55-69. DOI: 10.423/okic.2018. 82005
  17. Mahmoudi, F., Farhadi, S., Dusek, M. and Poupon, M. (2020)., Synthesis, Spectroscopy and X-ray Crystallography Structure of Pyridine 4-Carbaldehyde Semicarbazone Schiff Base Ligand., Advanced Journal of Chemistry – section A, 3(4), 534-541. Doi. 10.33945/ SAMI/AJCA. 4. 14
  18. Siraj, I. T. and Sambo, B. U. (2018)., Synthesis, Characterization and Antimicrobial Activities of Schiff base Derived from Thiourea and Anisaldehyde and its Mn(II), Fe(II) and Co(II) complexes., Bayero Journal of Pure and Applied Sciences, 11(1), 20-24.
  19. Mishra, L. and Pandey, A. K. (1992)., Spectroscopic, Electrochemical and Antifungal Studies of Transition Metal Complexes with Macrocyclics Containing Nitrogen and Sulphur Donor Atoms., Polyhedron, 11(4), 243-430. https://doi.org/10.1016/S0277-5387(00)83197-6
  20. Kavitha, J., Sakhthikumar, L. and Mahalakshmy, R. (2018)., Synthesis, Spectral and Biological Studies of Mixed Ligand Transition Metal Complexes of Nitroketenedithioacetal with Ephedrine., Indo American Journal of Pharmaceutical Sciences, 5(1), 645-658.
  21. El-ajaily, M. M., Abdelkarem, M., Himmet, M., Hamil, A. M. and Baghdadi, H. A. (2012)., Preparation, Spectroscopic Characterization and Antibacterial Activity of New Schiff Base Complexes., International Journal of Research in Pharmaceutical and Biomedical Sciences, 3(4), 1464-1468.