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Spectroscopic study of cyanotoxicity of potassium cyanide on normal human haemoglobin

Author Affiliations

  • 1Medical Biochemical and Pharmacognosy Research Unit, Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Nigeria
  • 2Natural Science Unit, School of General Science, University of Nigeria, Nsukka, Enugu State, Nigeria
  • 3Medical Biochemical and Pharmacognosy Research Unit, Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Nigeria.

Res.J.chem.sci., Volume 10, Issue (3), Pages 1-9, October,18 (2020)

Abstract

Potassium cyanide (KCN) one of the salts of cyanide finds its application in several fields of endeavour such as pharmaceuticals, industrial, agricultural, mining, metallurgy, medical, photography and as a biological weapon. Release of cyanide from KCN into the blood stream during its usage has been found to be toxic to human health. Sequel to this, the study aims atinvestigating by spectral analysis, the cyanotoxicity effect of KCN on normal human haemoglobin. The study was divided into 8 groups consisting of control and test groups (0.2, 0.5, 1 and 1.5M KCN + 1000Ál Oxyhaemoglobin respectively and 2000, 3000 and 4000Ál Oxyhaemoglobin + 1.5M KCN respectively). It was found that KCN caused concentration dependent oxidation on normal human haemoglobin and also a concentration dependent reduction in oxyhaemoglobin concentration which are all precursors to several pathophysiologic conditions in man. Therefore, measures should be put in place to curtail the hazardous effect of cyanide emission on human.

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