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Synthesis, Spectral and Pharmacological Study of Cu(II), Ni(II) and Co(II) Coordination Complexes

Author Affiliations

  • 1Dept. of Applied Sc. and Humanities, Haryana Engineering College, Jagadhri – 135003, Haryana, INDIA

Res.J.chem.sci., Volume 1, Issue (5), Pages 1-5, August,18 (2011)


Complexes of Cu(II), Ni(II) and Co(II) with 2,5–Dihydroxy butyrophenone thiosemicarbazone(L) / 2,5–Dihydroxy benzophenone thiosemicarbazone(L) as primary ligand and 2,2’-bipyridyl(L) as a secondary ligand have been synthesized. Complexes were characterized by analytical data, molar conductance, magnetic measurement, electronic spectra, IR spectra and thermogravimetric analysis. The stereochemistry of the coordination complexes has been confirmed on the basis of electronic, spectral and magnetic moment studies. Racah’s interelectronic parameter(B), Cubic Ligand field splitting parameter (10 Dq) and Nephelauxetic ratio(), g, , h have also been calculated and it has been found that the values are in accordance with the stereochemical structure of the coordination complexes. Elemental analysis and spectral studies suggest the octahedral stereochemistry for all the complexes. Ligands and their complexes with Cu(II), Ni(II) and Co(II) were also screened for their inhibitory effects against four organisms viz; S.aureus, B.megaterium, B.cereus and E.coli by cupplate method. The results of the evaluation of antibacterial activity show that all the synthesized complexes exhibit considerable activities towards all the four pathogenic bacteria. The activity of the mixed complexes has been found to be greater than those of the metal salts and ligands. Moreover, it has also been noticed that the thiosemicarbazones show low activity towards E. coli.


  1. You Y., Zheng X., Young R. and Ahn B., Archiv. Pharma. Res., 989, 163 (1989)
  2. Singh N.K., Singh S.B., Shrivastav A. and Singh S.M., Spectral, magnetic and biological studies of l,4-dibenzoyl-3-thiosemicarbazide complexes with some first row transition metal ions, Proceedings of the Indian Academy of Sciences: Chemical Sciences, 113(4), 257–273 (2001)
  3. Afrasiabi Z and Sinn E. et al., Appended 1, 2-naphthoquinones as anticancer agents: synthesis, structural, spectral and antitumor activities of ortho-naphthaquinone thiosemicarbazone and its transition metal complexes, Inorganica Chimica Acta, 357(1), 271–278 (2004)
  4. Chandra S., Sangeetika Rathi A., Magnetic and spectral studies on copper(II) complexes of N-O and N-S donor ligands, Journal of Saudi Chemical Society, 5(2), 175–182 (2001)
  5. Jouad E.M., Larcher G. and Allain M., et al., Synthesis, structure and biological activity of nickel(II) complexes of 5-methyl 2-furfural thiosemicarbazone, Journal of Inorganic Biochemistry, 86(2-3), 565–571 (2001)
  6. Sharma S., Athar F., Maurya M.R., Naqvi F. and Azam A., Novel bidentate complexes of Cu(II) derived from 5-nitrofuran-2-carboxaldehyde thiosemicarbazones with antiamoebic activity against E. histolytica, European Journal of Medicinal Chemistry, 40(6), 557–562 (2005)
  7. Quenelle D.C., Keith K.A. and Kern E.R., In vitro and in vivo evaluation of isatin -thiosemicarbazone and marboran against vaccinia and cowpox virus infections, Antiviral Research, 71(1), 24–30 (2006)
  8. Vogel A.I.,A Text book of Quantitative AnalysisRevised by Bessett J., Denny R.C., Jeffery J.H., Mendham J., ELBS, th Edn., (1996)
  9. Geary W.T., Coord. Chem. Rev., 7, 81 (1971)
  10. Levason W and Auliffe M.C., Inorg. Chem., 13, 321 (1988)
  11. Raman N., Kulandaisamy A., Shunmugasudram A. and Jeyasubramanianm K., Trans. Met. Chem., 26,131(2001)
  12. Cotton F.A. and Wilkinson G., Advanced Inorganic chemistry – Interscience (N.Y.)., (1967)
  13. Knopp P., Woeghardt K., Nuber B., Weuss J. and Sheldrick W.S., Inorg Chem.,29, 363 (1990)
  14. Chandra S. and Kumar A., Spectral studies on Co(II), Ni(II) and Cu(II) complexes with thiosemicarbazone and semicarbazone derived from 2-acetyl furan, Spectrochimica Acta Part A., 66(4-5), 1347–1351 (2007)
  15. Anjaneyula Y. and Rao R.P., Synth- React Inorg. Met. Org. Chem.,26, 257 (1986)
  16. Dharmaraj N., Viswanathamurthi P. and Natarajan K., Trans. Met. Chem.,26, 105(2001)
  17. Vallance R.H., Twiss D.F. and Russell A.R., A text book of Inorg. Chem., Ist Edn, 383 (1931)
  18. Nakamoto K., Infrared and Raman Spectra of inorganic and coordination compounds, 3rd Edn.(Wiley, New York) (1977)
  19. Colthup N.B., Daby L.H. and Wiberly S.E., Introduction to infrared and Raman Spectroscopy,Academic Press New York 311(1964)
  20. Colton F.A. and Goodgame D.M.L, J. Am. Chem. Soc., 83, 1780(1961)
  21. Mceleverty J.A., Gill S.A., Kowalski R.S.Z., Bailey N.A., Adams H., Lumbard K.W. and Murphy M.A., J. Chem. Soc. Dalton Trans., 493 (1982)
  22. Andrews P.C., Koutsanonis G.A. and Raston C.L,J. Chem. Soc. Dalton Trans., 4059 (1995)
  23. Colonna C., Doucet J.P. and Crosse Barbi A., Trans. Met. Chem.,20, 338(1995)
  24. Oswal S.L. and Phalak R.P., Int J. Thermophys., 13, 251 (1992)
  25. Pal A. and Singh Y.P., J. Chem. Thermodyn., 26, 1063 (1994)
  26. Asmy E.L., Khalifa A.A. and Hassanian M. M., Ind. J. Chem., 43A, 92 (2004)
  27. Viswanthanmurhty G.A., Karvembu R. and Natarajan K., Ind. J Chem., 44A, 90 (2005)
  28. Rajanarendar E., Karunkar D. and Ramu K.,Heterocyclic Commun., 12, 213 (2006)
  29. Hania M.M., E-Journal of Chemistry, 6S1, 508 (2009)
  30. Malik S., Ghosh S. and Jain Bharti, J. Ind. Council Chem.,27, 173-176 (2010)