International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Anti-Rheumatic and Antioxidant activity of extract of Stem bark of Ficus bengalensis

    , , , ,

Author Affiliations

  • 1Swami Vivekanand college of Pharmacy, Indore, INDIA
  • 2Suresh Gyan Vihar University, Jaipur, INDIA
  • 3B.M College of Pharmaceutical Sciences, Indore, INDIA

Res.J.chem.sci., Volume 1, Issue (2), Pages 2-8, May,18 (2011)

Abstract

Ficus bengalensis Linn (Moraceae) is commonly known as Banyan tree or Bargad. It possesses medicinal properties and in ayurveda is used in diuretic, hypoglycemic, anti-inflammatory agent and in diarechea. The analgesic, anti rheumatic and ant-oxidant activity of the methanolic extract of the bark of Ficus bengalensis (MFB) were studied at doses of 100, 200 and 300 mg/kg (i.p) using the Freund’s Complete Adjuvant induced arthritis model, the Formalin induced arthritis model and the Agar induced arthritis model. The extract produced marked inhibitory effect on edema especially on secondary immunological arthritis and caused graded inhibition of both phases of Formalin- induced pain .The present study validates the traditional use, demonstrating that the methanolic extract of bark of Ficus bengalensis possesses dose –dependent anti-rheumatic activity in all the models with a possibility of acting through the central and peripherally mediated activities. The DPPH and hydrogen peroxide model demonstrated positive antioxidant activity in a concentration dependent manner(100g/ml).

References

  1. Kirtikar K. R. and Basu B. D., Indian Medicinal Plants, International Book Distributor, Dehradun, India, 2312 (2004)
  2. Nadkarni K. M., Indian Materia Medica, Edn, Vol. I, Popular Book Depot, 544 (1955)
  3. Subramanian P. M. and Mishra G. S., Chemical constituents of Ficus bengalensis, Pol. J. Pharm.,30(4), 559-62 (1978)
  4. Augusti K. T. and Daniel R. S., Antidiabetic effect of Leucocyanidine derivative isolated from bark of F.bengalensis, Indian J. Biochem Biophy,29, 380-82 (1992)
  5. Augusti K. T., Hypoglycaemic action of bengalenoside, a glycoside, isolated from F. Bengalensis in normal and alloxan diabetic rabbits, Indian J. Physiol. Pharmacol., 19, 218-220 (1975)
  6. Augusti K. T. and Cherian B., Effect of Leucopelargonin derivative from Ficusbengalensis Linn, On diabetic dogs, Ind J. Med .Res.,99, 82-86 (1994)
  7. Cherian S. and Augusti K. T., Antidiabetic effect of Leucopelargonidin, Indian Exp. Bio, 31 (1), 26 -29 (1993)
  8. Geetha A. and August K. T., Hypoglycaemic effects of Leucodelphinidin derivative isolated from F. bengalensis, Ind. J. Physiol Pharmacol,38, 220 (1994)
  9. Rimi Shukla and Shweta Gupta, Antioxidant effect of aqueous extract of bark of F. Bengalensis, J. of Ethnopharmacology, 92 (1), 47-51 (2004)
  10. Gabhe S. Y., Tatke P. A. and Khan T. A., Evaluation of immunomodulatory activity of methanol extract of F.bengalensis, Ind. J. Pharmacology, 38(4), 271-275 (2006)
  11. Patil V. V. and Pimpirikar R. B., Pharmacognistical studies and evaluation of anti-inflammatory activity of Ficus bengalensis, Journal Young Pharmacists, 49-53 (2009)
  12. Mukherjee K., Pulok 2002, Kokate C. K., 1996, Khandelwal K. R., Practical Pharmacognosy, 67-70 (2006)
  13. Khandelwal, K. R., Kokate C. K., Gokhale S. R., Practical Pharmacognosy Techniques And Experiments, Nirali Prakashan Publications, 104-106 (1996)
  14. Zimmermann M., Ethical guidelines for investigation of experimental pain in conscious animals, Pain, 16, 109-10 (1983)
  15. Organization of Economical and Cooperation Development Guidelines for the Testing of chemicals-Acute Oral Toxicity up and Down Procedure, 425 (2006)
  16. Newbould B. B., Brit J. Pharmacol, 21, 127 (1963)
  17. Dubuisson D., and Dennis S. G., Pain, 4, 161 (1977)
  18. Okoli C. O., Akah P. A., Nwafor S. V. and Adams C. D., Anti-inflammatory activity of hexane leaf extracts Aspilia Africana., J. Ethnopharmacol. 109, 219-225 (2007)
  19. Iwueke A. V., Nwodo O. F. C., Okoli C. O., Evaluation of anti-inflammatory and analgesic activities of Vitex doniana leaves, Af.r J. Biotech,5 (20), 1929-1935 (2006)
  20. Perez G. R. M., Anti-inflammatory activity of Ambrosia artemisiaefolia and Rheo spathaceae, Phytomed, 3, 163-167 (1993)
  21. Hunskaar S., Hole K., Pain, 30103, (1987)
  22. Lee O. K. and Jeong Y. S., Effects of different concentrations of Formalin on Paw edema and Pain Behaviors in Rats, Journal Korean Med Sci., 17, 81-85 (2002)
  23. Tjolsen A., Berge O. G., Hunskaar S., Rosland J. H., Hole K., Pain, 51, 5 (1992)
  24. Shibata M., Ohkubo T., Takahashi H., Inoki R., Pain, 38, 347 (1989)
  25. Rosland J. H., Tjoisen A. and Hole K., Pain 42, 235 (1990)
  26. Paras S. Kirankumar H. and Sakshy S., Evaluation of Anti-inflammatory activity of
  27. Cymopsis tetragonoloba seeds in rodents, Journal of Pharmacy Research, 3(1), 163-165, (2010)
  28. Sharma A., Bhardwaj S., Mann A. S., Jain A. and Kharya M. D., Screening Methods of Antioxidant Activity: An Overview, Phcog Rev,(2), 232-238 (2007)