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A Simple and Efficient Procedure for Synthesis of Biologically Active 1,2,4-Triazolo-[3,4-b]-1,3,4-thiadiazole -2-aryl-thiazolidine-4-one Derivatives

Author Affiliations

  • 1Department of Chemistry,Hemchandracharya North Gujarat University, Patan-384265, INDIA

Res.J.chem.sci., Volume 1, Issue (1), Pages 18-24, April,18 (2011)

Abstract

Some new and biologically active [1,2,4] triazolo [3,4-b][1,3,4] thiadiazole-2-aryl-thiazolidinone-4-ones were synthesized by reaction of Schiff bases with mercapto acetic acid in presence of THF with adding anhydrous ZnCl2. The structure of the synthesized compounds have been estabilished on the bases of IR, PMR, CMR and elemental analysis. The compounds have been evaluated for antibacterial activity againstB. subtilis,S. aureus, P. aeruginosa and E. coli.

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