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Effect of High Fat Diet and High Protein Diet on Fasting Serum Ghrelin Level in Type-1 Diabetes

Author Affiliations

  • 1 Dept. of Pharmacology, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, Ajman, UNITED ARAB EMIRATES

Int. Res. J. Medical Sci., Volume 3, Issue (6), Pages 5-14, June,28 (2015)

Abstract

Ghrelin is a multifunctional orexigenic peptide that is related to the regulation of the feeding behavior, energy homeostasis, growth hormone release and alsoit has evidenced relation with insulin. In normal weight and non-diabetic conditions, the ghrelin response to food depends completely on the type of macronutrients, but this relation with the type of macroneutrient is not clear in obese or diabetic conditions. In this work we studied the effect of high fat diet (HFD) and high protein diet (HPD) on ghrelin level in type I diabetic lean and obese rats aiming to clarify the role of these diets. The work was conducted on 5 groups of rats each consisted of 10 rats. Body weight was measured at the onset of the study, after 2 weeks then at the end of the study period; 8 weeks. After 8 weeks blood samples were collected and analyzed for fasting serum glucose and ghrelin levels. Results showed a significant reduction in the serum ghrelin level in the HFD diabetic group as compared to both the control diabetic and HFD fed group while the HPD diabetic rats showed significant increase in serum ghrelin level compared to both the control and HFD groups and insignificant difference compared to the control diabetic group. We concluded that HFD significantly reduces ghrelin in diabetic rats while HPD in spite of being more satiating, its effects on ghrelin secretion is not clear in type 1 diabetes.

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