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A correlation between Serum Vitamin, Acetylcholinesterase Activity and IQ in Children with Excessive Endemic Fluoride exposure in Rajasthan, India

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Author Affiliations

  • 1 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Department of Advance Science, NIMS University, Jaipur – 303121, INDIA
  • 2 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Department of Advance Science, NIMS University, Jaipur – 303121, INDIA
  • 3 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Department of Advance Science, NIMS University, Jaipur – 303121, INDIA
  • 4 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Department of Advance Science, NIMS University, Jaipur – 303121, INDIA
  • 5 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Departments of Psychiatry, NIMS Medical College and Hospital, NIMS University, Jaipur - 303121 INDIA
  • 6 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Departments of Orthopedics, NIMS Medical College and Hospital, NIMS University, Jaipur - 303121 INDIA
  • 7 National Referral Center for Fluoride Poisoning in India, Nims University, Jaipur INDIA and Departments of Pediatrics, NIMS Medical College and Hospital, NIMS University, Jaipur - 303121 INDIA

Int. Res. J. Medical Sci., Volume 1, Issue (3), Pages 12-16, April,28 (2013)

Abstract

Fluoride is widely distributed in nature and a direct source of adverse health effects in human populations. Fluoride poisoning attributed by long-term exposure to high levels of fluoride called fluorosis. The present study was carried out among 9-14 years old school children of Dausa district, Rajasthan India. The subjects were selected from high fluoride region (2.0 ppm) and age matched were selected from Jaipur district where fluoride content was (1.5 ppm). A set of question was used to collect information from the children's personal character, clinical health outcome, residential record, educational achievements and family socioeconomic status. Fluoride in serum, urine and drinking water were estimated in both subjects and controls along with serum vitamin (A, C, D and E) and acetylcholinesterase (AChE). The Raven's Standard Progressive Matrices was used to measurement of children's intelligence. IQ scores and serum F levels was directly correlated with the concentration of serum F level. Reduced concentration of vitamin (C, D and E) and AChE activity is the potent markers of neuro-degeneration. The conclusion of the study is that the excessive fluoride delineates the neuronal impairment which were evident by reduce IQ score and serum AChE activity. Moreover, the altered vitamin concentrations which may further lead to brain and bone damage.

References

  1. Mangukiya R., Bhattacharya T. and Chakraborty S., Quality Characterization of Groundwater using Water Quality Index in Surat city, Gujarat, India, Int. Res. J. Environment Sci., 1(4), 14-23 (2012)
  2. Koul N., Lokhande R.S. and Dhar J.K., Physico-Chemical, Bacteriological and Pesticide analysis of Tap Water in Millennium City Gurgoan, Haryana, India, I. Res. J. Environment Sci.,1(2), 1-7 (2012)
  3. Mohamed H.M. and Hussain Zahir A., Study of Groundwater Quality at Dindigul Town, Tamilnadu, India, Int. Res. J. Environment Sci., 2(1), 68-73, (2013)
  4. Veeraputhiran V. and Alagumuthu G., Treatment of High Fluoride Drinking Water Using Bioadsorbent, Res.J.Chem.Sci.,1(4), 49-54 (2011)
  5. WHO World Health Organization, Environmental Guidelines by WHO for drinking water quality, 1-3, (1984)
  6. Chakma T. and Rao V.P., A biannual newsletter of regional medical research centre for tribals Jabalpur, fluorosis and human health, 1(2), (2004)
  7. Samal U.N. and Naik B.N., Dental Fluorosis in school children in the vicinity of an Aluminium factory in India, Fluoride, 21, 142-148 (1988)
  8. Yadav A.K., Jain P.K. and Lal S., Geochemical study of fluoride in groundwaterof Behror tehsil of Alwar district (Rajasthan), Res. J. Chem. Environ., 43-47 (2003)
  9. Zhao L.B., Liang G.H., Zhang D.N., Wu X.R., Effect of a high fluoride water supply on children’s intelligence, Fluoride, 29, 190-2 (1996)
  10. Lu Y., Sun Z.R., Wu L.N., Wang X., Lu W., Liu S.S.,Study of cognitive function impairment caused by fluorosis, Fluoride, 33, 74-8 (2000)
  11. Trivedi M.H., Verma R.J., Chinoy N.J., Patel R.S., Sathawara N.G., Effect of high water on children’s intelligence in India, Fluoride, 40, 178-83 (2007)
  12. Sharma J.D., Sohu D., Jain P., Prevalence of neurological manifestations in a human population exposed to fluoride in drinking water, Fluoride, 42, 127–32 (2009)
  13. Uttara Bayani, Singh A.V., Zamboni P. and Mahajan R.T., Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options Curr Neuropharmacol, 7(1), 65–74 (2009)
  14. Raven J.C., Court J.H. and Raven J., Raven manual: The standard progressive matrices, Oxford: Oxford Psychologists Press, (1992)
  15. Saxena S., Sahay A. and Goel P., Effect of fluoride exposure on the intelligence of school children in Madhya Pradesh, India Year, Jour. of neurosc. In rural. Prac., 3(2), 144-149 (2012)
  16. Craft N.E., Bulux J., Valdez C., Li Y., Solomons N.W., Retinol concentrations in capillary dried blood spots from healthy volunteers: method validation, Am J Clin Nutr., 72(2), 450-454 (2000)
  17. 7.Lowry H., Jeanne A., Lopez and Otto A., The determination of ascorbic acid in small amounts of blood serum, Journal of Biological Chemistry, 162, 609-615 (1945)
  18. Baker H., Frank O., Gowenlock A.H., Murray J.R., Mchauchian D.M., Determination of serum tocopherol, In: In Alan Gowenlock editor: Varley’s Practical clinical chemistry, 902-903 (1968)
  19. Ellman C.L., Courtney D., Andres V., Featherstone R., A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem. Pharmacol., 88-95 (1961)
  20. Hodge, Harold C., Smith, Frank A., Occupational Fluoride Exposure, J. Occupa. Med., 19(1),12-39, (1977)
  21. Villa A., Anabalon M. and Cabezas L., The fractional urinary fluoride excretion in young children understable fluoride intake conditions, Community Dent Oral Epidemiol, 28, 344-55 (2000)
  22. Ailani V., Gupta R.C., Gupta S.K. and Gupta K., Oxidative stress in case of chronic fluoride intoxication, Indian Journal of Clinical Biochemistry, 24(4), 426-429 (2009)
  23. Li Yuxin, Berenji G.R., Shaba W.F., Taftia B., Yevdayev E. and Dadparvar S., Association of vascular fluoride uptake with vascular calcification and coronary artery disease, Nuclear Med Comm, 33, 14-20 (2012)
  24. Song A.H., Wang T.Y., Zhang Z.B., Jiang C.Y., Observations on fluorotic aorta sclerosis by two-dimensional echo cardiography, Endemic Diseases Bulletin, (1), 91-93 (1990)
  25. Liang C.K., Ji R. and Cao S.R., Epidemiological analysis of endemic fluorosis in China, Environmental Carcinogenesis and Ecotoxicology Reviews, 15(2), 123–138 (1997)
  26. Uttara B., Singh A.V., Zamboni P. and Mahajan R.T., Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options, Curr Neuropharmacol., 7(1), 65–74 (2009)
  27. McCann J.C. and Ames N.B., Vitamin C function and status in chronic disease, Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction, Nutr Clin Care., 5(2), 66-74 (2002)
  28. Raven J.C., Court J.H. and Raven J., Raven manual: The standard progressive matrices. Oxford: Oxford Psychologists Press , (1992)
  29. Benton D. and Roberts G., Effect of vitamin and mineral supplementation on intelligence of a sample of school children, The Lancet, 1, 140-3 (1988)
  30. Brown A.J., Dusso A.S., Slatopolsky E., Vitamin analogues for secondary hyperparathyroidism, Nephrol Dial Transplant, 17(10), 10-9 (2002)