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The Role of Natural Antioxidants in Oxidative Stress Induced Diabetes Mellitus

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Author Affiliations

  • 1Suresh Gyan Vihar University, Jaipur, Rajasthan, INDIA
  • 2 B.M. College of Pharmaceutical Education and Research, Indore, MP, INDIA

Res. J. of Pharmaceutical Sci., Volume 3, Issue (4), Pages 1-6, April,30 (2014)

Abstract

Diabetes mellitus is a group of metabolic disorder disturbing around 1.5% of the entire population that persisting to present a global health trouble. It is characterized by abnormally elevated levels of blood glucose due to complete or relative insufficiency in insulin secretion and /or insulin action together with chronic hyperglycemia as well as disturbances in carbohydrate, fat and protein metabolism. Diabetes mellitus is coupled with an imbalance among generation of oxygen free radicals and endogenous antioxidant defense that leads to the development of oxidative stress which is partially responsible for diabetes as well as its complications. Several studies have recommended that oxidative stress play a major role in reduced secretion of pancreatic cells, systemic inflammation, endothelial damage and impaired glucose consumption in peripheral tissues, where absolute treatment with insulin as well as oral hypoglycemic agents with no side effect has been difficult. On the other hand, use of antioxidants can be an apparent substitute in patients with diabetes mellitus. Antioxidants obtained from nature helps in neutralization of reactive oxygen species and significantly reduce the probability of progression of diabetic complications. A variety of nutritionally important vitamins, supplements and some constituents of natural food sources including cappers, broccoli, tomatoes, berries, grapes, spinach, carrots, nuts, etc. naturally reduce the injury caused by oxidative stress in diabetes mellitus. Natural products are better known for their traditional use; moreover pharmacy professionals having a sufficient knowledge of such natural products are in a better position to guide patients on their proper use. This review describes the importance of naturally occurring antioxidant in management of diabetes mellitus and its complications.

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