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Materials Saving and Waste Minimization in Indian Pharmaceutical Industries

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Author Affiliations

  • 1Department of Civil Engineering, Jadavpur University, Kolkata, INDIA
  • 2 Dept. of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Metro Garden City, Pailan, D.H. Road, Kolkata, INDIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (2), Pages 20-25, February,30 (2013)

Abstract

This paper presents different techniques suggested for cleaner production in three pharmaceutical plants. The main focus of this paper is towards evaluation of source reduction and waste minimization. This paper also finds the various other possibilities to reuse the waste produced in the above-mentioned unit. All input materials, starting from raw materials, potable water, purified water, and water for injection and polyethylene granules are so quantified as to fix limit for all raw materials as 2.5 EU/ gm determined through Bacterial Endotoxin Test (BET). An extensive literature review presents different approaches made by leading pharmaceutical industries to save materials and to minimize wastes generated. Attempts to replace organic solvents by aqueous media have been proved to be successful in all respects.It is successfully experimented that in large volume parenterals industry a measure of endotoxin test at raw material stage, intermediate stage and finished stage could save a huge loss of product rejection resulting in saving of materials and waste minimization.Existing formulation of raw materials should be audited time to time to find the scope for reduction of excipients for resource reduction and waste minimization..

References

  1. Bhatti P.D., Roy S., Aggarwal R., Dash R., Sekhar M. and Kaliprasad V., Cleaner Production in Dye Manufacturing Clusture, Waste Minimisation Circle News,4(1), 3-9, (2003)
  2. Nodubuisi Ezejiofor Tobias I, Duru Carissa I., Asagbra Agnes E, Ezejiofor Anthonet N., Orisakwe Orish E., Afonne Johnson O. and Obi Ejeatuluchukwu, Waste to wealth: Production of oxytetracycline using streptomyces species from household kitchen wastes of agricultural produce, African Journal of Biotechnology, 11(43), 10115-10124 (2012)
  3. APPCB Information Bulletin, Opportunities for Waste Minimisation in Bulk Drug and dye intermediate Industries, Publication no.105, April (1999)
  4. Energy Efficiency workshop, Approach and Case studies, presented by S.K. Lasod, Lupin Limited, Ankleshwar, Available at : ent-india.net/Presentation2010/26-Fertiliser /LupinPharma (2010)
  5. Taylor Nick, GSK aims to cut time to clinic with excipient-free compression, 8th Febtuary, (2012) , in-pharmatechnologist.com/Ingredients/GS
  6. Mohan B. Krishna, Pharma firms look to profit from waste, Business Standard(2009)
  7. ParibeshR. and D of Central Pollution Control Board, Annual report (2003)
  8. Krishna Mohan B., May15, Business Standard (2009)
  9. Green Chemistry commitments and actions Pfizer : the world’s largest research based pharmaceutical company, July4, (2012) available,on Pfizer.com /responsibility /protecting_environment/green_chemistry_commitments.jsp
  10. Grate J., Huisman G., A greener biocatalytic manufacturing route to sitagliptin Paper presented at 13th annual Green Chemistry and Engineering Conference, June 23, College Park, Md. (2009)
  11. Martinez C.A., Hu S. and Dumond Y., et.al. Development of a Chemoenzymatic manufacturing process for pregabalin, Organic Process Res. Dev. (2008)
  12. Jennewein S., Schurmann M. and Wolberg M., et.al Directed evolution of an industrial biocatalyst: 2- deoxy-D-ribose 5-phosphate aldolase, Biotechnol. J.,1(5) 537-548 (2006)
  13. Roger A. Sheldon Catalyst: The Key to Waste Minimization, J. Chem. Tech. Biotechnol., 68 381-388 (1997)
  14. Enteric coating, available at Wikipedia.org /wiki /Enteric_coating (2012)
  15. Indian Pharmacopoeia, Volume II, page 1686-1687, Government of India, Ministry of Health and Family welfare, Indian Pharmacopoeia Commission, Ghaziabad (2010)
  16. Indian Pharmacopoeia (2010) , Addendum, Government of India, Ministry of Health and Family welfare, Indian Pharmacopoeia Commission, Ghaziabad 2940-2941 (2012)
  17. Indian Pharmacopoeia, Government of India, Ministry of Health and Family welfare, Indian Pharmacopoeia Commission, Ghaziabad, III, 1861-1862 (2010)