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Simple Titrimetric Method for the Estimation of Salbutamol Sulphate (SBS) in Pharmaceutical Formulations

Author Affiliations

  • 1Department of Chemistry and Post Graduate-Research Center, Abeda Inamdar Sr. College, Pune, INDIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (1), Pages 11-14, January,30 (2013)

Abstract

A titrimetric method which is simple, sensitive and rapid is described for the assay of salbutamol sulphate (SBS) in bulk drug and in tablet dosage forms using N-bromosuccinimide (NBS) as reagents. In titrimetry, aqueous solution of salbutamol sulphate is treated with a measured excess of NBS in acetic acid medium and after the oxidation of SBS is complete, the unreacted oxidant is determined iodometrically.In this method the amount of NBS reacting corresponds to the amount of SBS content. Titrimetric method is applicable over 1.74 x 10–4 – 8.68 x 10–4 mol/L range and the reaction stoichiometry is found to be 1:6 (SBS: NBS). Intraday and inter-day precision and accuracy for the developed method was evaluated. The method was successfully applied to the assay of SBS in tablet and capsule formulations and the results were statistically compared with those of a reference method. The accuracy and reliability of the methods were further ascertained by recovery experiments via the standard-addition technique.

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