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Synthesis, Characterisation and Biological Activity of Chiral Mixed Ligand Ni(II) Complexes

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Author Affiliations

  • 1Department of Chemistry, the Institute of Science, 15, Madam Cama Road, Mumbai, Maharashtra, INDIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (1), Pages 1-10, January,30 (2013)

Abstract

Chiral Mixed Ligand (CML) metal complexes of the type [M(PMINAP)(aa)2H2O], where M is Ni(II), PMINAP is sodium salt of p-methoxyisonitrosoacetophenone and aa is a chiral amino acid have been synthesized. The present CML metal complexes could also be synthesized from racemic amino acids by in situ stereoselective complexation. The metal complexes have been characterized by elemental analysis and various physico-chemical techniques. The bonding and structure of the complexes are discussed in detail on the basis of the results of various studies. The metal complexes have been screened for their biological activity against selected microbial strains.

References

  1. Mrinalinil L. and Manihar Singh A.K., mixed ligand Co(III) complexes with 1-amidino-O-methyl urea and amino acids, Res. J. Chem. Sci., 2(1), 45-49 (2012)
  2. Girgaonkar M.V. and Shirodkar S.G., synthesis, characterization and biological studies of Cu(II) and Ni(II) complexes with new bidentate schiff’s base ligands as 4-hydroxy-3-(1-(arylimino)ethyl) chromen-2-one, Res. J. Recent Sci.,1(ISC-2011)
  3. 110-116 (2012)
  4. Agarwal Ram K., Sharma Deepak and Agarwal Himanshu., synthesis, biological, spectral and thermal investigation of cobalt(II) and nickel(II) complexes of N-isoniotinamido-2,4-dichlorobenzaldimine, Bioinorganic Chemistry and Applications., 1-9 (2006)
  5. Gupta Y.K., Agarwal S.C., Madnawat S.P. and Ram Narain., synthesis, characterization and antimicrobial studies of some transition metal complexes of Schiff bases, Res. J. Chem. Sci.,2(4), 68-71 (2012)
  6. Sankhala K. and Chaturvedi A., microwave assisted synthesis, characterization and antibacterial activity of some arsenic(III) derivatives of O-alkyl or O-aryl trithiophosphates, Res. J. Chem. Sci., 2(5), 57-65 (2012)
  7. Gazala Mohamed H. and Ben Hander., ternary complexes of cobalt(II) involving nitrilotriacetic acid and some biological active ligands, Res. J. Chem. Sci.,2(3), 12-20 (2012)
  8. Rajasekar K., Ramchandramoorthy T. and Paulraj A., microwave assisted synthesis, structural characterization and biological activities of 4-aminoantipyrine and thiocynate mixed ligand complexes, Res. J. of Pharmaceutical Sci., 1(4), 22-27 (2012)
  9. Hughes M.N., Coordination compounds in biology, Comprehensive Coordination Chemistry, Wilkinson G., Gillard R.D. and McCleverty J.A., Eds, Pergamon Press, Oxford, 6, 541-754 (1987)
  10. Freeman H.C., Metal complexes of amino acids and peptides, Inorganic Biochemistry,Eichhorn, G.L., Ed, Elsevier Scientific, Amsterdam, 1, 121-166 (1973)
  11. 0.Welcher F.J., Organic Analytical Reagents, De Van Nostrand, New York, 3, 273 (1955)
  12. Furnis B.S., Hannaford A.J., Smith P.W.G. and Tatchell A.R., Solvents and reagents, Vogel's Textbook of Practical Organic Chemistry, 5th Edn., ELBS, Longman, London, 395-412 (1989)
  13. Vogel A.I., In A Textbook of Quantitative Inorganic Analysis, 3rdEdn., ELBS, Longman Green, London, (1961)
  14. Datta R.L. and Syamal A., Elements of Magnetochemistry, 2ndEdn., Affiliated East-West Press Pvt. Ltd, New Delhi, (2004)
  15. Hugo W.B. and Russel A.D.,Pharmaceutical Microbiology, 6thEdn., Blackwell Science Publication. 15.Geary W.J., The use of conductivity measurements in organic solvents for the characterization of coordination compounds, Coord. Chem. Rev., 7(1), 81-122 (1971)
  16. Thakkar N.V. and Patil R.M., Synthesis of mononuclear metal complexes with some tetradentate Schiff base ligands, Synth. React. Inorg. Met.-Org. Chem., 30(6), 1159-1174 (2000)
  17. Thakkar N.V. and Deshmukh R. G., Indian J. Chem.,33(A),224 (1994)
  18. Thakkar N.V. and Halder B. C., J. Inorg. Nucl. Chem., 42,843(1980)
  19. Nakamoto K., Latiice water and aquo and hydroxo complexes, Infrared and Raman spectra of Inorganic and coordination compounds, 4th Edn., John-Wiley and Sons, New York, 227-231(1986)
  20. Nakamoto K., Morimoto Y. and Martell A.E., Infrared spectra of aqueous solutions. Metal chelate compounds of amino acids, J. Am. Chem. Soc., 83 4528-4532 (1961)
  21. Hamrit H., Djebbar-Sid S., Benali-Baitich O., Khan M.A. and Bouet G., Potentiometric studies, synthesis and characterization of mixed ligand complexes of copper(II), nickel(II), cobalt(II) and Manganese(II) with N-(2-acetamidoiminodiacetic) acid as the primary ligand and histidine as the secondary one, Synth. React. Inorg. Met.-Org. Chem., 30(10), 1835-1848 (2000)
  22. Ballhausen C.J., Introduction to Ligand Field Theory, McGraw-Hill, New York (1962)
  23. Orgel L.E., Spectra of transition metal complexes, J. Chem. Phys., 23, 1004-1014 (1955)
  24. König E., The nephelauxetic effect, Structure and Bonding, Hemmerich P., Jørgensen C.K., Neilands J.B., Nybolm R.S., Reinen D. and Williams R.J.P., Eds., Springer-Verlag, New York, 9, 175-212 (1971)
  25. Sutton D., Furthur aspects, covalency in transition metal complexes, Electronic Spectra of Transition Metal Complexes, McGraw-Hill, London, 150-163 (1965)
  26. Carlin R.L., Transition Metal Chemistry., Marcel Dekker, New York, (1965)
  27. Banerjea D., Coordination Chemistry., 3rd Edn., Asian Books Pvt. Ltd., New Delhi., 393-394 (2009)
  28. Patil R.M., Synthesis and studies on diamine dependant structural features of Co(II), Ni(II) and Cu(II) complexes with some Schiff base ligands., Ph.D. Thesis., University of Mumbai (1999)
  29. Patil R.M., Synhetic, structural and biological properties of binuclear complexes with some schiff bases, Acta Poloniae Pharmaceutica-Drug Research., 64(4), 345-353 (2007)
  30. Martell A.E. and Calvin M., Uses of chelating agents, Chemistry of the Metal Chelate Compounds, Prentice-Hall, New York, 471-512 (1952)
  31. Madigan M.T., Martinko J.M. and Parker J., Microbial growth control. Biology of Microorganisms, 8th Edn., Prentice-Hall: New Jersey, 397-429 (1997)
  32. Chohan Z.H., Misbahul A.K. and Moazzam M., Synthesis, characterization and antimicrobial studies of Co(II) and Ni(II) complexes with some pyrazoles, Indian J. Chem.,27(A), 1102-1104 (1988)