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A review on in vitro genotoxic effects of food Preservatives on Human Lymphocytes

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Author Affiliations

  • 1Department of Zoology, Gujarat University, Ahmedabad 380 009, India
  • 2Disha Life Sciences Pvt. Ltd, Sr. Research Associate, Ahmedabad 380 051, India

Int. Res. J. Biological Sci., Volume 6, Issue (7), Pages 15-18, July,10 (2017)

Abstract

Food Preservatives or other food additives are use to protect food from spoilage. Preservatives have hazards effects on human’s organs and also have effects on individual cell. The different concentration of preservatives affects the chromosomes which lead to chromosomal breakage. Human lymphocytes are used for Genotoxic study of preservatives. Micronucleus test, Sister Chromatid Exchanges and Chromosomal aberration studies are used. Lymphocytes cell culture carried out with 4-5 different concentrations of preservatives and results of different studies were comparing with control values. 24 and 48 hrs. treatments of preservatives are given to lymphocytes and from their results the range of concentration are prepared which cannot be hazards for human’s daily intake. This concentration range of preservatives can be later on approved by Food and Drug Administration.

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