Antimicrobial property of Capsaicin
- 1Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India
- 2Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India
- 3Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India
- 4Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India
Int. Res. J. Biological Sci., Volume 6, Issue (7), Pages 7-11, July,10 (2017)
Antimicrobial agents have always been of clinical significance. The effectiveness of antibiotics in the near future is unpredictable due to increasing antibiotic resistance among common pathogenic microbial strains. Capsaicin, the active ingredient in chillies has numerous biological properties which are yet to be explored. Due to its characteristic pungent nature, it has attracted interest in the field of antimicrobial studies, especially in the past two decades. In the current study, pure capsaicin at different concentrations and the Soxhlet extract of Bhut jolokia (India’s ‘hottest’ chilli) were screened for their antimicrobial effects on the common pathogenic bacterial strains Salmonella paratyphi A, Salmonella paratyphi B, Proteus mirabilis and Micrococcus luteus as an extensive literature study revealed no screening performed on these strains. Antimicrobial activity was observed in Salmonella paratyphi A, Salmonella paratyphi B and M. luteus with M. luteus showing the maximum susceptibility. In this age of antibiotic resistance and emergence of pathogenic microbial mutants, it is of significant importance to have knowledge about secondary antimicrobial compounds apart from the currently known antibiotics. In a different aspect, a genetic relationship can be established between eukaryotes and prokaryotes which respond to capsaicin due a common receptor gene.
- Liu M., Lu J., Muller P., Turnbull L., Burke C.M., Schlothauer R.C. and Harry E.J. (2014)., Antibiotic-specific differences in the response of Staphylococcus aureus to treatment with antimicrobials combined with manuka honey., Frontiers in Microbiology, 5(12), 779. https://doi.org/10.3389/fmicb.2014.00779
- Capsaicin (2017)., National Center for Biotechnology Information., PubChem Compound Database; CID = 1548943, https://pubchem.ncbi.nlm.nih.gov/compound /1548943 (Accessed Feb. 27, 2017).
- Tewksbury J.J., Reagan K.M., Machnicki N.J., Carlo T.A., Haak D.C., Penaloza A.L.C. and Levey D.J. (2008)., Evolutionary ecology of pungency in wild chilies., Proceedings of the National Academy of Sciences, 105(33), 11808-11811. https://doi.org/10.1073/pnas.0802691105
- Anand P. and Bley K. (2011)., Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch., British Journal of Anaesthesia, 107(4), 490-502. http://dx.doi.org/10.1093/bja/aer260
- Jones N.L., Shabib S. and Sherman P.M. (1997)., Capsaicin as an inhibitor of the growth of the gastric pathogen Helicobacter pylori., FEMS Microbiology Letters, 146(2), 223-227. https://doi.org/10.1111/j.1574-6968.1997.tb10197.x
- Omolo M.A., Wong Z., Mergen A.K., Hastings J.C., Le N.C., Reil H.A., Case K.A. and Baumler D.J. (2014)., Antimicrobial Properties of Chili Peppers., Journal of Infectious Diseases and Therapy, 02(04), para.11. https://doi.org/10.4172/2332-0877.1000145
- Agrocrops (2015)., Red Dry Chilies., http://www.agrocrops.com/red-dry-chillies.php (Accessed Aug. 28, 2016).
- Guinness World Records (2013)., Hottest Chili., http://www.guinnessworldrecords.com/world-records/ hottest-chili (Accessed Feb. 27, 2017).
- Cayenne Diane (2017)., Bhut Jolokia(Ghost Pepper)., https://www.cayennediane.com/peppers/bhut-jolokia-ghost-pepper (Accessed 27 Feb. 2017)
- European Centre for Disease Prevention and Control (2015)., Typhoid and paratyphoid fever, . http://ecdc.europa.eu/en/healthtopics/typhoid_paratyphoid_fever/Pages/index.aspx. (Accessed 6 Mar 2017)
- Rowe B., Ward L.R. and Threlfall E.J. (1997)., Multidrug-Resistant Salmonella typhi: A Worldwide Epidemic., Clinical Infectious Diseases, 24(1), S106-S109. http://dx.doi.org/10.1093/clinids/24.Supplement_1.S106
- Microbewiki (2017)., Proteus mirabilis., https://microbewiki.kenyon.edu/index.php/Proteus_mirabilis (Accessed 6 Mar. 2017)
- Adamus-Bialek W., Zajac E., Parniewski P. and Kaca W. (2013)., Comparison of antibiotic resistance patterns in collections of Escherichia coli and Proteus mirabilis uropathogenic strains., Molecular Biology Reports, 40(4), 3429-3435. https://doi.org/10.1007/s11033-012-2420-3
- Modmedmicrobes.wikispaces.com. Sarcina Lutea. https://modmedmicrobes.wikispaces.com/Sarcina+Lutea (Accessed 6 Mar. 2017), undefined, undefined
- Shiqiang Y., Xu X. and Yonghong Z. (2009)., Optimization of Soxhlet extraction of capsaicinoids using orthogonal experiment., Chinese scientific papers online, 2(Mar). http: //www.paper.edu.cn/releasepaper/ content/ 200903-2.