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Analysis of Cytochrome P51A1 gene, its Sequence Variants and Protein Domains

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Author Affiliations

  • 1Department of Biotechnology, University of South Asia, Lahore, Pakistan
  • 2Department of Biotechnology, University of South Asia, Lahore, Pakistan

Int. Res. J. Biological Sci., Volume 5, Issue (8), Pages 17-21, August,10 (2016)

Abstract

The cytochrome gene CYP51 is a member of the cytochrome P450 (CYP) gene super family and is mainly involved in synthesis of sterolby chemical reactions in certain plants and animals. CYP51 is commonly known across eukaryotes. The study is focused on functional analysis of human CYP51 gene, which is 22 kb in size with coding region consisting of 10 exons and present on chromosome number7 long arm position 7q21.2–q21.3. However, the comparison of the human CYP51 gene with other CYP gene families from different species shows 64 different CYP51 orthologues which are located at unique chromosomal positions. Computational analysis of CYP51 gene was performed to analyze its various orthologues, genetic variants, protein domains and signatures.

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