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Insilico identification of novel compound against Urinary Tract Infection

Author Affiliations

  • 1BIITP Trainee, Biotech Consortium India Limited, New Delhi, India
  • 2R and D Division, MRD Life Sciences Pvt Ltd, Lucknow, U.P, India
  • 3BIITP Trainee, Biotech Consortium India Limited, New Delhi, India
  • 4BIITP Trainee, Biotech Consortium India Limited, New Delhi, India

Int. Res. J. Biological Sci., Volume 5, Issue (3), Pages 51-55, March,10 (2016)

Abstract

Urinary tract infections are one of the widest diseases in India nowadays. There are only limited diagnoses about the major cause of infection to initiate UTIs in humans. Most of the UTIs are caused by bacteria and fungus and are one of the most common indications for rapid increase in antibiotics usage for UTIs. FimH are surface organelles of Escherichia coli, responsible for UTIs, found on the tip of Escherichia coli pili that interact with oligomannose on urothelial cells of urinary tract. We selected six Benzimidazole derivatives, that exhibits antimicrobial activity, were docked against the FimH protein. The docking analysis of FimH against six Benzimidazole derivatives revealed that all six Benzimidazole derivatives have potential to work against UTIs, but 1-{1-[(2Z)-3-(3-chlorophenyl) prop-2-enoyl]-1H-benzimidazol-2-yl}ethanol (-8.04 kcal/mol) fits better than the rest. Some of the commonly used drugs to treat UTIs include Ciprofloxin, Fosfomycin, Levofloxacin and Nitrofurantoin these drugs were subjected to docking analysis for comparative studies.

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