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Ameliorative Effect of Rocket Leaves on Fertility in Streptozotocin-Induced Diabetic Rats

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Author Affiliations

  • 1Department of Pharmacology, College of Pharmacy, Salman Bin Abdulaziz University, Al-Kharj, KINGDOM OF SAUDI ARABIA

Int. Res. J. Biological Sci., Volume 3, Issue (8), Pages 14.ISCA-IRJBS, August,10 (2014)

Abstract

In the present study, Rocket leaves were evaluated for the acute toxicity and fertility of male diabetic rats. Leaves were subjected to extraction with water. Extract was administered orally to Swiss albino mice to explore their acute toxic effects (LD50). For the fertility experiment, 24 rats were divided into 4 groups, containing 6 rats in each group; one group serve as normal control, while in others groups, animals were rendered diabetic by single injection of STZ (55 mg/kg, i.p.). One group serving as diabetic control, and the others two groups were treated with aqueous extract of rocket (AER) at doses of 250 and 500 mg/kg for 8 consecutive weeks. Animal were assessed for fertility protective activity after 24h of the last dose. The results showed significant (p0.01) increase in the sexual organ weights (testes, epididymis, seminal vesicles and prostate) and serum quality in the AER treated groups when compared with the diabetic control group in dose dependent manner. AER was also found to increase serum testosterone, testicular GSH level and decreased testicular TBARS levels. The obtained results demonstrated that AER significantly improve diabetes complications in rat’s testis. The present study suggested that rocket might have a promising effect against diabetes-induced impaired testicular damage in male rats.

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