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Epidemiology Study of Human Metapneumovirus in Malaysia among Paediatric Children below 4 years of age, 2012

Author Affiliations

  • 1Virology Unit, Infectious Diseases Research Centre, Institute for Medical Research, 50588, Kuala Lumpur, MALAYSIA
  • 2Department of Molecular Biology, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak Malaysia, 94300 Kota Samarahan, Sarawak, MALAYSIA
  • 3Institute of Biological Sciences, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
  • 4Department of Medicine, Shanmuganathan Engineering College, Shanmuganathan Engineering College, Thirumayam, Tamil Nadu, INDIA

Int. Res. J. Biological Sci., Volume 3, Issue (6), Pages 24-28, June,10 (2014)

Abstract

We have done a specific study on the molecular epidemiology of Human Metapneumovirus cases which was found in Malaysia among paediatric children below 48 months of age from January till December 2012. These paediatric cases were isolated from the rest of those entire positive below 48 months of age. The total number of the positive cases below 48 months of age is 53 cases out of the general population of 438 positive cases. We performed phylogenetic analysis on these patients and a seasonal prevalence hMPV incidence was observed in the month of November. A high level of sequence identity was observed in the A2 subgroup and no amino acid substitution was found compared to the strains observed in Malaysia and other countries. The pairwise distance among the strains belonging to the predominant subgroup A2was0.0925 suggesting highly homologous with seasonal epidemics.

References

  1. Monto A.S. and Sullivan K.M., Acute respiratory illness in the community, Frequency of illness and the agents involved, Epidemiol Infect, 111, 14540 (1993)
  2. Loh T.P., F.Y.L. Lai E.S. Tan., et al., Correlations between clinical illness, respiratory virus infections and climate factors in a tropical pediatrics population, Epidemiology and Infection, 139, 1884-1894 (2011)
  3. Van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease, Nat Med.,, 719– 724 (2001)
  4. Murray C., A. Lopez, C. Mathers, and C. Stein, The Global Burden of Disease 2000 project: aims, methods and data sources, In Global programme on evidence for health policy, World Health Organization, Geneva, Switzerland (2001)
  5. Pelletier G., Dery P., Abed Y. and Boivin G., Respiratory tract reinfections by the new human metapneumovirus in an immunocompromised child, Emerg. Infect. Dis., 976-978 (2002)
  6. Carr M.J., Waters A., Fenwick F., Toms G.L. and Hall W.W., Molecular epidemiology of human metapneumovirus in Ireland, J Med Virol, 80, 510–516 (2008)
  7. Tamura K., Peterson D., Peterson N., Stecher G., Nei M., and Kumar S), MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony(2011)
  8. Jukes T.H. and Cantor C.R., Evolution of protein molecules, In Munro HN, editor, Mammalian Protein Metabolism, 21-132, Academic Press, New York (1969)
  9. Nei M. and Kumar S., Molecular Evolution and Phylogenetics. Oxford University Press, Oxford/New York, (2000)
  10. Tamerius J.D., Shaman J. and Alonso W.J. et al., Environmental predictors of seasonal influenza epidemics across temperate and tropical climates, PLoS Pathogens(2013)
  11. Cannizzo E, Clement C, Morozova K, Valdor R, Kaushik S, Almeida L, Follo C, Sahu R, Cuervo A, Macian F. and Santambrogio L., Age-related oxidative stress compromises endosomal proteostasis, Cell Rep., 26,2(1), 136-49 (2012)
  12. Jensen-Fangel S., Mohey R., Johnsen S.P., Andersen P.L., Sørensen H.T., Ostergaard L., Gender differences in hospitalization rates for respiratory tract infections in Danish youth, Scand J Infect Dis., 36(1), 31-6 (2004)