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Comparison of Therapeutic effects of the Myrtus communis Nano-essence and Topical 1% terbinafine cream in Guinea pigs infected by microsporum canis

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Author Affiliations

  • 1Department of Small animal medicine, Science and Research branch, Islamic Azad University, Tehran, IRAN
  • 2Department of Mycology, Science and Research branch, Islamic Azad University, Tehran, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (3), Pages 23-29, March,10 (2014)

Abstract

The use of traditional medicine for centuries to treat various illnesses, is known in many societies.Nanoparticle drug carriers are very important because it carries a variety of drugs to the different parts of the body.They can effectively deliver the drug to a target site and thus increase the therapeutic benefit, while minimizing side effects. In this study, Myrtus communis nanoessence was used to treat dermatophytosis caused by Microsporum canis (M.canis) in an experiment on guinea pigs. In vivo and in vitro methods were used to investigate the antifungal properties of the nanoessence. Minimum inhibitory concentration of nanoessence was 3.2-6.5 µg/ml. The treatment was started 5 days after infection as 12 hours regimen for 40 days after the infection. Both treatment groups, terbinafine and nanoessence, were completely cured over the 40-day period. Results show that the nanoessence under study is an effective drug to treat Microsporum canis caused by dermatophytosis.

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