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Hepatoprotective Role of Curcumin against Acetaminophen induced toxicity in rats

Author Affiliations

  • 1 Department of Biochemistry, Dr. R.M.L. Avadh University, Faizabad, UP, INDIA
  • 2 Department of Biochemistry, Banaras Hindu University, Varanasi, UP, INDIA

Int. Res. J. Biological Sci., Volume 2, Issue (12), Pages 42-49, December,10 (2013)

Abstract

Acetaminophen (APAP) induced hepatotoxicity causes severe hepatic damages for which no specific treatment is available. Consequently, the present study is aimed at evaluating the antioxidant effects of curcumin (CMN) on APAP-exposed hepatic damages. Adult male Wistar Albino rats were treated orally with different concentration (0.0 mM -50 mM) of APAP intraperitoneally to induce hepatotoxicity. Twenty-four hours post administration of acetaminophen; rats were sacrificed to measure hepatocytes viability, level of malondialdehyde (MDA), calcium ATPas activity and antioxidant enzyme activity. Results suggest that with an increase in APAP concentration there was decrease in hepatocytes viability, calcium ATPase activity but marked elevation of malondialdehyde. CMN is a well known nutraceutical with potent antioxidant properties. CMN markedly increased hepatocytes viability, calcium ATPase activity and reduced the elevated malondialdehyde levels. The results indicate the therapeutic importance of CMN in overcoming acetaminophen induced hepatotoxicity. It is therefore necessary to explore the role of CMN in treatment of hepatic damages.

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