Purification of Cinnamaldehyde from Cinnamon Species by Column Chromatography

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Purification of Cinnamaldehyde from Cinnamon Species by Column Chromatography

Author Affiliations

¹Centre of Biotechnology, Department of Chemical Engineering, AUCE (A), Andhra University, Visakhapatnam 530003, INDIA

Int. Res. J. Biological Sci., Volume 1, Issue (7), Pages 49-51, November,10 (2012)

Abstract

Cinnamon belongs to the family of Lauraceae. This genus comprises over 250 species. It is widely distributed throughout tropical and sub-tropical areas. It is widely used as spice and used as herbal medicine. Cinnamon contains cinnamaldehyde, eugenol, cinnamic acid etc. Cinnamaldehyde gives flavour and odour to the cinnamon. The objectives of this work were extraction of cinnamaldehyde from cinnamon by batch studies and purify the cinnamaldehyde by using column chromatography. For the optimized physico-chemical parameters, the highest cinnamaldehyde concentration was observed to be 44.6mg/L and the concentration was increased to 52.0mg/L from the column chromatography.

References

Mikali P., Shayegh J., Saraharoodi S. and Sharifi M., Pharmacological Properties of Herbal oil Extracts Used In Iranian Traditional Medicine, Advances in Environmental Biology,6(1), 153-158 (2012)
Meena V., Sree Satya N., Surya Prakash D.V. and Sumanjali A., A Review on Pharmacological Activities and Clinical effects of Cinnamon Species, Research Journal of Pharmaceutical, Biologial and Chemical Sciences, 3(1)653-663 (2012)
Sharma C.K. and Kanwar S.S., Synthesis of methyl cinnamate using immobilized lipase from B.licheniformis MTCC-1048. Research Journal of Recent Sciences, 1(3), 68-71 (2012)
Nenandis et al., Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values, Journal of Agricultural and Food Chemistry, 26, 295–299 (2004)
Shaik Mahaboob Ali., Aleem A Khan., Irshad Ahmed M.Musaddiq., Khaja S Ahmed., H.Polasa., L.Venkateswara Rao., Chittoor M Habibullah., Leonardo A Sechi. and NIyaz Ahmed., Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori, Annals of Clinical Microbilogy and Antimicrobials, 4(20), 1-7 (2005)
Youn H.S., Lee J.K., Choi Y.J., Saitoh S.I., Miyake K., Hwanq D.H. and Lee J.Y., Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization, Biochem Pharmacol, 75(2), 494-502 (2008)
Chang S.T., Chen P.F. and Chang S.C., Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum, Journal of Ethnopharmacology, 77(2), 123-127 (2001)
Fang H., Rao Y.K. and Tzeng Y.M., Cytotoxic effect of trans-Cinnamaldehyde from Cinnamomum osmophloeum Leaves on Human Cancer Cell Lines, Int. J. Appl. Sci. Eng, (2), 136-137 (2004)
Lee H.S., Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase, J. Pharm. Pharmaceut. Sci, 5(3), 226-230 (2002)
Schanderl S.H., In: Method in Food analysis Academic Press New York, 709
Sree Satya N., Surya Prakash D.V. and Meena V.,Optimization of physico-chemical parameters for the extraction of phenolic components from cinnamon species, Journal of Academia and Industrial Research. (In Press)

[ref1] Mikali P., Shayegh J., Saraharoodi S. and Sharifi M., Pharmacological Properties of Herbal oil Extracts Used In Iranian Traditional Medicine, Advances in Environmental Biology,6(1), 153-158 (2012)

[ref2] Meena V., Sree Satya N., Surya Prakash D.V. and Sumanjali A., A Review on Pharmacological Activities and Clinical effects of Cinnamon Species, Research Journal of Pharmaceutical, Biologial and Chemical Sciences, 3(1)653-663 (2012)

[ref3] Sharma C.K. and Kanwar S.S., Synthesis of methyl cinnamate using immobilized lipase from B.licheniformis MTCC-1048. Research Journal of Recent Sciences, 1(3), 68-71 (2012)

[ref4] Nenandis et al., Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values, Journal of Agricultural and Food Chemistry, 26, 295–299 (2004)

[ref5] Shaik Mahaboob Ali., Aleem A Khan., Irshad Ahmed M.Musaddiq., Khaja S Ahmed., H.Polasa., L.Venkateswara Rao., Chittoor M Habibullah., Leonardo A Sechi. and NIyaz Ahmed., Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori, Annals of Clinical Microbilogy and Antimicrobials, 4(20), 1-7 (2005)

[ref6] Youn H.S., Lee J.K., Choi Y.J., Saitoh S.I., Miyake K., Hwanq D.H. and Lee J.Y., Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization, Biochem Pharmacol, 75(2), 494-502 (2008)

[ref7] Chang S.T., Chen P.F. and Chang S.C., Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum, Journal of Ethnopharmacology, 77(2), 123-127 (2001)

[ref8] Fang H., Rao Y.K. and Tzeng Y.M., Cytotoxic effect of trans-Cinnamaldehyde from Cinnamomum osmophloeum Leaves on Human Cancer Cell Lines, Int. J. Appl. Sci. Eng, (2), 136-137 (2004)

[ref9] Lee H.S., Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase, J. Pharm. Pharmaceut. Sci, 5(3), 226-230 (2002)

[ref10] Schanderl S.H., In: Method in Food analysis Academic Press New York, 709

[ref11] Sree Satya N., Surya Prakash D.V. and Meena V.,Optimization of physico-chemical parameters for the extraction of phenolic components from cinnamon species, Journal of Academia and Industrial Research. (In Press)