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Anti-angiogenic properties of the Jamaican ball moss, (Tillandsia recurvata L.)

Author Affiliations

  • 1Bio-Tech R and D Institute, Kingston, JAMAICA
  • 2Educational and Scientific Corporation, Florida, USA
  • 3Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
  • 4Natural Products Institute, University of the West Indies, Mona, JAMAICA

Int. Res. J. Biological Sci., Volume 1, Issue (4), Pages 73-76, August,10 (2012)

Abstract

The island of Jamaica is known for its rich biodiversity and its abundance of medicinal plants being used as ethno medicines. Given the high occurrence of cancer worldwide and the major source of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the anti-angiogenic properties of a chloroform extract from the Jamaican ball moss previously shown to exhibit anti-cancer properties in our lab and its dicinnamate isolates,1,3-di-O-Cinnamoyl-glycerol (D1 ) and (E)-(2-(3-(3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydroxypropoxy)-2-oxoethyl)triphenylphosphoniumbromide (D2) along with known chemotherapeutic drug, paclitaxel. This was investigated using a modified version of the ex vivo aortic ring sprouting assay. Results show that angiogenesis was reduced in the presence of the chloroform crude extract at 20 µg.ml and 30 µg/ml and also in the presence of D1 at 10 µg/ml and 20 µg/ml when compared to the control. The results substantiate the promising anti-cancer properties of the Jamaican ball moss and may prove useful in anti-cancer agents’ drug discovery.

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