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Prospective use of Tephrosia Purpurea in Remedial Treatment of PCOS: Study in Wistar Rat

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Author Affiliations

  • 1Department of Zoology, Bhavans College, Andheri, Mumbai University, Mumbai, INDIA
  • 2Department of Biotechnology, N.B. Mehta Science College, Bordi, Mumbai University, Mumbai, INDIA

Int. Res. J. Biological Sci., Volume 1, Issue (3), Pages 1-6, July,10 (2012)

Abstract

This study evaluates the potential of an herbal plant Tephrosia purpurea, in treatment of polycystic ovary syndrome (PCOS) using a rat model. The study used female Albino Wistar rats, which were divided into four groups, each consisting of 5 female rats. A control group, daily received 1% CMC (carboxymethylcellulose), while the other three groups for 28 days were once, daily administered, letrozole at concentration of 1mg/kg body weight, dissolved in 1% CMC 2ml/kg. Vaginal smears were collected daily from all the groups and studied for the estrous cycle. During 28 days of administration of letrozole, changes in estrous cycle were observed. The study indicated that PCOS was induced. After letrozole treatment, five animals of group 2 were treated orally with plant drug Tephrosia purpurea at a concentration of 200mg/kg body weight in milk as a carrier vehicle, 3ml/kg weight for 3 consecutive estrous cycles, vaginal smear were examined, it showed normalcy in estrous cycle sequence. Further, to check ovulation and fertility, female rats were mated and they showed pregnancy. Thus the potential of Tephrosia purpurea, in treatment of polycystic ovary syndrome (PCOS) using an animal model is confirmed.

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